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Hematopoietic Cell Signal Transducer (HCST)

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DAP10; KAP10; PIK3AP; Phosphoinositide-3-Kinase Adaptor Protein; DNAX-Activation Protein 10; Kinase Assoc Pro of 10kDa; Transmembrane adapter protein KAP10

Hematopoietic Cell Signal Transducer (HCST)
CCC H924
HGNC 16977
MGI 1344360
PubMed 22342113
RGD 1359238
UniProt Q9UBK5
HCST encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.
Predominantly expressed in hemopoietic cells such as NK cells, subset of T-cells and monocytes. Detected in leukocytes, spleen, and thymus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hematopoietic Cell Signal Transducer (HCST) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hematopoietic Cell Signal Transducer (HCST) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hematopoietic Cell Signal Transducer (HCST) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hematopoietic Cell Signal Transducer (HCST) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hematopoietic Cell Signal Transducer (HCST) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hematopoietic Cell Signal Transducer (HCST) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hematopoietic Cell Signal Transducer (HCST) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hematopoietic Cell Signal Transducer (HCST) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hematopoietic Cell Signal Transducer (HCST) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hematopoietic Cell Signal Transducer (HCST) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hematopoietic Cell Signal Transducer (HCST) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hematopoietic Cell Signal Transducer (HCST) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hematopoietic Cell Signal Transducer (HCST) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hematopoietic Cell Signal Transducer (HCST) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hematopoietic Cell Signal Transducer (HCST) ELISA Kit Customized Service Offer
  1. "KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties."J. Immunol. 163:4651-4654(1999) [PubMed] [Europe PMC] [Abstract]
  2. "An activating immunoreceptor complex formed by NKG2D and DAP10."Science 285:730-732(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2D."Immunogenetics 53:243-249(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells."J. Exp. Med. 192:1059-1068(2000) [PubMed] [Europe PMC] [Abstract]
  8. "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells."J. Immunol. 168:671-679(2002) [PubMed] [Europe PMC] [Abstract]
  9. "NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway."Nat. Immunol. 4:557-564(2003) [PubMed] [Europe PMC] [Abstract]
  10. "NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases."Nat. Immunol. 4:565-572(2003) [PubMed] [Europe PMC] [Abstract]
  11. "A Structural basis for the association of DAP12 with mouse, but not human, NKG2D."J. Immunol. 173:2470-2478(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo."J. Immunol. 175:720-729(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells."J. Immunol. 175:7819-7828(2005) [PubMed] [Europe PMC] [Abstract]
  14. "The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure."Proc. Natl. Acad. Sci. U.S.A. 102:7641-7646(2005) [PubMed] [Europe PMC] [Abstract]
  15. "IL-21 down-regulates NKG2D/DAP10 expression on human NK and CD8+ T cells."J. Immunol. 176:1490-1497(2006) [PubMed] [Europe PMC] [Abstract]
  16. "NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells."Nat. Immunol. 7:524-532(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Regulation of human DAP10 gene expression in NK and T cells by Ap-1 transcription factors."J. Immunol. 180:409-417(2008) [PubMed] [Europe PMC] [Abstract]