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Hypermethylated In Cancer 1 (HIC1)

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ZBTB29; Zinc finger and BTB domain-containing protein 29

Hypermethylated In Cancer 1 (HIC1)
CCC H910
HGNC 4909
MGI 1338010
PubMed 24295734
RGD 1307527
UniProt Q14526
Wiki HIC1
Hic1 encodes a zinc finger protein with a poxvirus and zinc finger (POZ) domain. During embryonic development, Hic1 is expressed in mesenchymes of the sclerotomes, lateral body wall, limb, and craniofacial regions embedding the outgrowing peripheral nerves during their differentiation. During fetal development, Hic1 is also expressed in mesenchymes apposed to the precartilaginous condensations, at many interfaces to budding epithelia of inner organs, and weakly in musclesThe BTB/POZ domains of HIC1 and HIC2 heterodimerized and repressed transcription from a reporter plasmid. Inhibitor studies indicated that HIC1 and HIC2 do not recruit HDAC-containing complexes. The central GLDLSKK/R motif, which is conserved in HIC1 and HIC2, was found to interact with C-terminal-binding protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hypermethylated In Cancer 1 (HIC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hypermethylated In Cancer 1 (HIC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hypermethylated In Cancer 1 (HIC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hypermethylated In Cancer 1 (HIC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hypermethylated In Cancer 1 (HIC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hypermethylated In Cancer 1 (HIC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hypermethylated In Cancer 1 (HIC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hypermethylated In Cancer 1 (HIC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hypermethylated In Cancer 1 (HIC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hypermethylated In Cancer 1 (HIC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hypermethylated In Cancer 1 (HIC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hypermethylated In Cancer 1 (HIC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hypermethylated In Cancer 1 (HIC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hypermethylated In Cancer 1 (HIC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hypermethylated In Cancer 1 (HIC1) ELISA Kit Customized Service Offer
  1. "p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3."Nat. Med. 1:570-577(1995) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B."Proc. Natl. Acad. Sci. U.S.A. 96:14831-14836(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1."Biochem. Biophys. Res. Commun. 287:427-434(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif."Mol. Cell. Biol. 22:4890-4901(2002) [PubMed] [Europe PMC] [Abstract]
  6. "The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties."J. Biol. Chem. 279:38313-38324(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses."Cell 123:437-448(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Mechanism of fibroblast growth factor-binding protein 1 repression by TGF-beta."Biochem. Biophys. Res. Commun. 345:595-601(2006) [PubMed] [Europe PMC] [Abstract]
  9. "HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies."EMBO J. 25:2326-2337(2006) [PubMed] [Europe PMC] [Abstract]
  10. "A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP."FEBS J. 273:2879-2890(2006) [PubMed] [Europe PMC] [Abstract]
  11. "An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity."Mol. Cell. Biol. 27:2661-2675(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex."Proc. Natl. Acad. Sci. U.S.A. 104:829-833(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma."Genes Dev. 22:770-785(2008) [PubMed] [Europe PMC] [Abstract]
  14. ErratumGenes Dev. 22:1410-1410(2008)
  15. "HIC1 interacts with a specific subunit of SWI/SNF complexes, ARID1A/BAF250A."Biochem. Biophys. Res. Commun. 385:586-590(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1)."J. Biol. Chem. 284:20927-20935(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells."Mol. Cell. Biol. 30:4045-4059(2010) [PubMed] [Europe PMC] [Abstract]
  18. "A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1."Oncogene 29:2467-2476(2010) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]