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Major Histocompatibility Complex Binding Protein 1 (MBP1)

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HIVEP1; CIRIP; CRYBP1; PRDII-BF1; ZNF40; ZAS1; GAAP; Schnurri-1; Cirhin interaction protein; Zinc finger protein 40; Human immunodeficiency virus type I enhancer-binding 1

Major Histocompatibility Complex Binding Protein 1 (MBP1)
CCC H905
HGNC 4920
MGI 96100
PubMed 11161801
RGD 727847
UniProt P15822
Wiki HIVEP1
Members of the ZAS family, such as ZAS1 (HIVEP1), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV).
ZNF40, a protein that binds to these sequences, has a molecular mass of 298 kD and contains 2 widely separated zinc finger binding domains, each of which binds to the same DNA sequence. This protein has variously been known as HIVEP1, MBP1, and PRDII-BF1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Histocompatibility Complex Binding Protein 1 (MBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Histocompatibility Complex Binding Protein 1 (MBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Histocompatibility Complex Binding Protein 1 (MBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Major Histocompatibility Complex Binding Protein 1 (MBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Histocompatibility Complex Binding Protein 1 (MBP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Histocompatibility Complex Binding Protein 1 (MBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Histocompatibility Complex Binding Protein 1 (MBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Histocompatibility Complex Binding Protein 1 (MBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Major Histocompatibility Complex Binding Protein 1 (MBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Histocompatibility Complex Binding Protein 1 (MBP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Histocompatibility Complex Binding Protein 1 (MBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Histocompatibility Complex Binding Protein 1 (MBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Histocompatibility Complex Binding Protein 1 (MBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Major Histocompatibility Complex Binding Protein 1 (MBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Histocompatibility Complex Binding Protein 1 (MBP1) ELISA Kit Customized Service Offer
  1. "A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence."Genes Dev. 4:29-42(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Transcriptional regulator of genes involved in the control of cell growth or cell proliferation. Use of said regulator as a therapeutic or diagnostic agent."Patent number CA2448384, 12-DEC-2002
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes."Mol. Cell. Biol. 10:1406-1414(1990) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products."J. Virol. 66:244-250(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression."J. Virol. 68:1002-1009(1994) [PubMed] [Europe PMC] [Abstract]
  8. "GAAP-1: a transcriptional activator of p53 and IRF-1 possesses pro-apoptotic activity."EMBO Rep. 3:153-158(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Cirhin up-regulates a canonical NF-kappaB element through strong interaction with Cirip/HIVEP1."Exp. Cell Res. 315:3086-3098(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution."Biochemistry 29:9324-9334(1990) [PubMed] [Europe PMC] [Abstract]
  16. "High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1."Biochemistry 31:3907-3917(1992) [PubMed] [Europe PMC] [Abstract]