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Heparan Sulfate-3-O-Sulfotransferase 1 (HS3ST1)

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3OST; 3OST1; Heparan sulfate glucosamine 3-O-sulfotransferase 1

Heparan Sulfate-3-O-Sulfotransferase 1 (HS3ST1)
CCC H879
HGNC 5194
MGI 1201606
PubMed 20500673
RGD 71084
UniProt O14792
Wiki HS3ST1
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein.
The predicted 307-amino acid human 3OST protein shares 93% sequence similarity with mouse 3Ost. The 3OST protein contains a signal sequence and 5 potential N-glycosylation sites.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heparan Sulfate-3-O-Sulfotransferase 1 (HS3ST1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heparan Sulfate-3-O-Sulfotransferase 1 (HS3ST1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heparan Sulfate-3-O-Sulfotransferase 1 (HS3ST1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heparan Sulfate-3-O-Sulfotransferase 1 (HS3ST1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heparan Sulfate-3-O-Sulfotransferase 1 (HS3ST1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heparan Sulfate-3-O-Sulfotransferase 1 (HS3ST1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heparan Sulfate-3-O-Sulfotransferase 1 (HS3ST1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heparan Sulfate-3-O-Sulfotransferase 1 (HS3ST1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heparan Sulfate-3-O-Sulfotransferase 1 (HS3ST1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heparan Sulfate-3-O-Sulfotransferase 1 (HS3ST1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heparan Sulfate-3-O-Sulfotransferase 1 (HS3ST1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heparan Sulfate-3-O-Sulfotransferase 1 (HS3ST1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heparan Sulfate-3-O-Sulfotransferase 1 (HS3ST1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heparan Sulfate-3-O-Sulfotransferase 1 (HS3ST1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heparan Sulfate-3-O-Sulfotransferase 1 (HS3ST1) ELISA Kit Customized Service Offer
  1. "Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase."J. Biol. Chem. 272:28008-28019(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Purification of heparan sulfate D-glucosaminyl 3-O-sulfotransferase."J. Biol. Chem. 271:27072-27082(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities."J. Biol. Chem. 274:5185-5192(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci."J. Biol. Chem. 274:5170-5184(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of human heparan sulfate glucosamine 3-o-sulfotransferase 1 in complex with PAP."Submitted (JUN-2005) to the PDB data bank