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Heparan Sulfate-6-O-Sulfotransferase 1 (HS6ST1)

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HS6ST

Heparan Sulfate-6-O-Sulfotransferase 1 (HS6ST1)
CCC H878
HGNC 5201
MGI 1354958
PubMed 24501377
RGD 1309218
UniProt O60243
HS6ST1 is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biological activities. This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. This enzyme does not share significant sequence similarity with other known sulfotransferases.
The predicted 401-amino acid human HS6ST protein is a type II transmembrane protein, with an N-terminal transmembrane domain. A putative cleavage site occurs near the C-terminal end of the transmembrane domain.HS6ST contains 2 potential N-glycosylation sites.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH878Hu01 Recombinant Heparan Sulfate-6-O-Sulfotransferase 1 (HS6ST1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH878Hu21 Monoclonal Antibody to Heparan Sulfate-6-O-Sulfotransferase 1 (HS6ST1) WB; IHC; ICC; IP.
PAH878Hu01 Polyclonal Antibody to Heparan Sulfate-6-O-Sulfotransferase 1 (HS6ST1) WB; IHC; ICC; IP.
Assay Kits SEH878Hu ELISA Kit for Heparan Sulfate-6-O-Sulfotransferase 1 (HS6ST1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heparan Sulfate-6-O-Sulfotransferase 1 (HS6ST1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heparan Sulfate-6-O-Sulfotransferase 1 (HS6ST1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heparan Sulfate-6-O-Sulfotransferase 1 (HS6ST1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heparan Sulfate-6-O-Sulfotransferase 1 (HS6ST1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heparan Sulfate-6-O-Sulfotransferase 1 (HS6ST1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heparan Sulfate-6-O-Sulfotransferase 1 (HS6ST1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heparan Sulfate-6-O-Sulfotransferase 1 (HS6ST1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heparan Sulfate-6-O-Sulfotransferase 1 (HS6ST1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heparan Sulfate-6-O-Sulfotransferase 1 (HS6ST1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heparan Sulfate-6-O-Sulfotransferase 1 (HS6ST1) ELISA Kit Customized Service Offer
  1. "Molecular characterization and expression of heparan-sulfate 6-sulfotransferase."J. Biol. Chem. 273:9208-9213(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism."Proc. Natl. Acad. Sci. U.S.A. 108:11524-11529(2011) [PubMed] [Europe PMC] [Abstract]
  6. "The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients." J. Clin. Endocrinol. Metab. 99:E2138-2143(2014) [PubMed] [Europe PMC] [Abstract]