Heparan Sulfate-6-O-Sulfotransferase 3 (HS6ST3)

Heparan sulfate (HS) sulfotransferases, such as HS6ST3, modify HS to generate structures required for interactions between HS and a variety of proteins. These interactions are implicated in proliferation and differentiation, adhesion, migration, inflammation, blood coagulation, and other diverse processes.

The deduced 470-amino acid protein has characteristics of a type II transmembrane protein, with a short N-terminal segment followed by a hydrophobic sequence. It also contains 6 N-glycosylation sites. Northern blot analysis of adult mouse tissues detected tissue-specific expression of several Hs6st3 transcripts.Hs6st3 was also secreted into the culture medium. Hs6st3 showed 6-O-sulfotransferase activity against HS, N-sulfated heparosan, heparin, and some HS derivatives.