Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1)
[Edit]TAPP1; Tandem PH Domain Containing Protein-1; PH domain-containing family A member 1
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The last 3 C-terminal amino acids of TAPP1 are predicted to interact with PDZ domain-containing proteins. TAPP1 and TAPP2 share 58% identity over the first 300 amino acids, which encompass both PH domains. There is little homology in the C termini. Northern blot analysis detected a 4.0-kb transcript expressed in all tissues examined, with highest levels in skeletal muscle, spleen, lung, thymus, and placenta.
TAPP1 possessed a 5-fold higher affinity for PtdIns(3,4)P2 than TAPP2. Mutation of the conserved arg212 to leucine within the PPBM of the second PH domain of TAPP1 reduced or eliminated PtdIns(3,4)P2 binding. The N-terminal PH domain contributed to the affinity with which the C-terminal PH domain bound to PtdIns(3,4)P2.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPH871Hu01 | Recombinant Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAH871Hu01 | Polyclonal Antibody to Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPH871Mu01 | Recombinant Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAH871Mu01 | Polyclonal Antibody to Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Pleckstrin Homology Domain Containing Family A, Member 1 (PLEKHA1) | ELISA Kit Customized Service Offer |
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