≡

Patatin Like Phospholipase Domain Containing Protein 3 (PNPLA3)

[Edit]

ADPN; C22orf20; iPLA(2)epsilon; Adiponutrin; Acylglycerol O-acyltransferase; Calcium-independent phospholipase A2-epsilon

Patatin Like Phospholipase Domain Containing Protein 3 (PNPLA3)
CCC H868
HGNC 18590
MGI 2151796
PubMed 21068004
RGD 1595843
UniProt Q9NST1
Wiki PNPLA3
PNPLA3 is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes.
The glucose-induced increase in Adpn expression could be countered by agents known to raise intracellular cAMP. In vivo, Adpn mRNA was high in white and brown adipose tissue from fed mice, but it dropped to barely detectable levels after 19 hours of fast. Refeeding for 8 hours reversed the drop in Adpn mRNA. Fas and Srebp1c mRNA exhibited a similar pattern of expression. Just after a feeding period, Zucker fa/fa obese rats showed 30- to 50-fold elevation of Adpn mRNA relative to congenic lean controls.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH868Hu01 Recombinant Patatin Like Phospholipase Domain Containing Protein 3 (PNPLA3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH868Hu21 Monoclonal Antibody to Patatin Like Phospholipase Domain Containing Protein 3 (PNPLA3) WB; IHC; ICC; IP.
PAH868Hu01 Polyclonal Antibody to Patatin Like Phospholipase Domain Containing Protein 3 (PNPLA3) WB; IHC; ICC; IP.
Assay Kits SEH868Hu ELISA Kit for Patatin Like Phospholipase Domain Containing Protein 3 (PNPLA3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Patatin Like Phospholipase Domain Containing Protein 3 (PNPLA3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Patatin Like Phospholipase Domain Containing Protein 3 (PNPLA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Patatin Like Phospholipase Domain Containing Protein 3 (PNPLA3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Patatin Like Phospholipase Domain Containing Protein 3 (PNPLA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Patatin Like Phospholipase Domain Containing Protein 3 (PNPLA3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH868Ra01 Recombinant Patatin Like Phospholipase Domain Containing Protein 3 (PNPLA3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH868Ra21 Monoclonal Antibody to Patatin Like Phospholipase Domain Containing Protein 3 (PNPLA3) WB; IHC; ICC; IP.
PAH868Ra01 Polyclonal Antibody to Patatin Like Phospholipase Domain Containing Protein 3 (PNPLA3) WB; IHC; ICC; IP.
Assay Kits SEH868Ra ELISA Kit for Patatin Like Phospholipase Domain Containing Protein 3 (PNPLA3) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Reevaluating human gene annotation: a second-generation analysis of chromosome 22."Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract]
  2. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities."J. Biol. Chem. 279:48968-48975(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Adiponutrin: A new gene regulated by energy balance in human adipose tissue."J. Clin. Endocrinol. Metab. 89:2684-2689(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Polymorphisms in the adiponutrin gene are associated with increased insulin secretion and obesity."Eur. J. Endocrinol. 159:577-583(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease."Nat. Genet. 40:1461-1465(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans."Diabetologia 52:1056-1060(2009) [PubMed] [Europe PMC] [Abstract]
  11. "A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis."J. Biol. Chem. 285:6706-6715(2010) [PubMed] [Europe PMC] [Abstract]
  12. "A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity."J. Lipid Res. 50:2111-2116(2009) [PubMed] [Europe PMC] [Abstract]