Immature Colon Carcinoma Transcript 1 (ICT1)
[Edit]DS-1; MRP-L58; Immature colon carcinoma transcript 1 protein; Digestion substraction 1; 39S ribosomal protein L58; Peptidyl-tRNA hydrolase ICT1, mitochondrial
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The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Deviation from the normal maturation pathway by neoplastic transformation is thought to initiate in stem cells or their early descendants. This cDNA represented an mRNA of approximately 900 bp that was downregulated during differentiation of HT29-D4 and Caco-2 colon carcinoma cells and was not influenced by cell density. Southern blot analysis indicated that ICT1 is present as a single copy gene in the human genome. The longest ICT1 cDNA encodes a putative protein of 206 amino acids with a molecular mass of 24 kD. Western blot analysis of HT29-D4 protein extracts using polyclonal antiserum against a synthesized peptide from the C terminus of the putative protein revealed 2 specific bands of 25 and 20 kD.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Immature Colon Carcinoma Transcript 1 (ICT1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Immature Colon Carcinoma Transcript 1 (ICT1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Immature Colon Carcinoma Transcript 1 (ICT1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Immature Colon Carcinoma Transcript 1 (ICT1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Immature Colon Carcinoma Transcript 1 (ICT1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Immature Colon Carcinoma Transcript 1 (ICT1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Immature Colon Carcinoma Transcript 1 (ICT1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Immature Colon Carcinoma Transcript 1 (ICT1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Immature Colon Carcinoma Transcript 1 (ICT1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Immature Colon Carcinoma Transcript 1 (ICT1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Immature Colon Carcinoma Transcript 1 (ICT1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Immature Colon Carcinoma Transcript 1 (ICT1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Immature Colon Carcinoma Transcript 1 (ICT1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Immature Colon Carcinoma Transcript 1 (ICT1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Immature Colon Carcinoma Transcript 1 (ICT1) | ELISA Kit Customized Service Offer |
- "Identification of mRNAs that show modulated expression during colon carcinoma cell differentiation."Eur. J. Biochem. 234:843-848(1995) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome."EMBO J. 29:1116-1125(2010) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome."Front. Physiol. 4:183-183(2013) [PubMed] [Europe PMC] [Abstract]