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Inhibitor Of Growth Family, Member 5 (ING5)

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p28ING5

Inhibitor Of Growth Family, Member 5 (ING5)
CCC H805
HGNC 19421
MGI 1913512
PubMed 12750254
RGD 1307908
UniProt Q8WYH8
Wiki ING5
ING5 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.
ING5 was associated with 2 different histone acetyltransferase complexes, one containing HBO1 (MYST2) and the other containing MOZ (MYST3) and MORF (MYST4). In vitro acetyltransferase assays indicated that the histone specificity of the 2 complexes differed, with the ING5-HBO1 complex targeting histone H4 and the ING5-MOZ-MORF complex targeting H3.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inhibitor Of Growth Family, Member 5 (ING5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inhibitor Of Growth Family, Member 5 (ING5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inhibitor Of Growth Family, Member 5 (ING5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inhibitor Of Growth Family, Member 5 (ING5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inhibitor Of Growth Family, Member 5 (ING5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inhibitor Of Growth Family, Member 5 (ING5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inhibitor Of Growth Family, Member 5 (ING5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inhibitor Of Growth Family, Member 5 (ING5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inhibitor Of Growth Family, Member 5 (ING5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inhibitor Of Growth Family, Member 5 (ING5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inhibitor Of Growth Family, Member 5 (ING5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inhibitor Of Growth Family, Member 5 (ING5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inhibitor Of Growth Family, Member 5 (ING5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inhibitor Of Growth Family, Member 5 (ING5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inhibitor Of Growth Family, Member 5 (ING5) ELISA Kit Customized Service Offer
  1. "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity."Cancer Res. 63:2373-2378(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
  7. "ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression." Nature 442:96-99(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes."Mol. Cell. Biol. 28:6828-6843(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide."Proteins 72:1371-1376(2008) [PubMed] [Europe PMC] [Abstract]