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Integrator Complex Subunit 3 (INTS3)

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INT3; C1orf193; C1orf60; SOSS-A; Sensor of single-strand DNA complex subunit A

Integrator Complex Subunit 3 (INTS3)
CCC H793
HGNC 26153
MGI 2140050
PubMed 16239144
RGD 1304593
UniProt Q68E01
Wiki INTS3
INTS3 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1) and U2 (RNU2) . INTS3 is also a subunit of single-stranded DNA (ssDNA)-binding complexes involved in the maintenance of genome stability. SOSSA served as the central assembly factor, and SOSSB and SOSSC bound overlapping regions on SOSSA, but they did not interact directly with each other. Depletion of SOSSA by small interfering RNA led to dramatic decreases in SOSSB1 and SOSSB2 protein levels, abrogated targeting of SOSSB1 and SOSSB2 to chromatin, increased ionizing radiation sensitivity, caused defective G2/M checkpoint, and impaired homologous recombination repair.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrator Complex Subunit 3 (INTS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrator Complex Subunit 3 (INTS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrator Complex Subunit 3 (INTS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrator Complex Subunit 3 (INTS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrator Complex Subunit 3 (INTS3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrator Complex Subunit 3 (INTS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrator Complex Subunit 3 (INTS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrator Complex Subunit 3 (INTS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrator Complex Subunit 3 (INTS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrator Complex Subunit 3 (INTS3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrator Complex Subunit 3 (INTS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrator Complex Subunit 3 (INTS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrator Complex Subunit 3 (INTS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrator Complex Subunit 3 (INTS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrator Complex Subunit 3 (INTS3) ELISA Kit Customized Service Offer
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