Inter Alpha-Globulin Inhibitor H3 (ITIH3)
[Edit]H3P; SHAP; Pre-Alpha(Globulin)Inhibitor,H3 Polypeptide; Serum-derived hyaluronan-associated protein
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Enghild et al. (1989) found that one ITI member, the pre-alpha-trypsin inhibitor (P-alpha-I), is an approximately 130-kD protein that contains the mature ITIH3 heavy chain (HC3) and a 30-kD subunit. Bourguignon et al. (1993) stated that P-alpha-I is composed of HC3 covalently linked to bikunin, a Kunitz-type protease inhibitor. They reported that the 885-amino acid H3 precursor protein contains a 10-amino acid propeptide and a 19-amino acid signal peptide. Before or during linkage to bikunin, the C-terminal 238 amino acids are cleaved to produce mature HC3. H3 shares 54% and 41% identity with the H1 and H2 precursor proteins, respectively. Diarra-Mehrpour et al. (1998) corrected the cDNA sequence reported by Bourguignon et al. (1993).
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPH777Hu01 | Recombinant Inter Alpha-Globulin Inhibitor H3 (ITIH3) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAH777Hu01 | Polyclonal Antibody to Inter Alpha-Globulin Inhibitor H3 (ITIH3) | WB,IHC |
MAH777Hu21 | Monoclonal Antibody to Inter Alpha-Globulin Inhibitor H3 (ITIH3) | WB; IHC; ICC; IP. | |
Assay Kits | SEH777Hu | ELISA Kit for Inter Alpha-Globulin Inhibitor H3 (ITIH3) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Inter Alpha-Globulin Inhibitor H3 (ITIH3) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Inter Alpha-Globulin Inhibitor H3 (ITIH3) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Inter Alpha-Globulin Inhibitor H3 (ITIH3) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Inter Alpha-Globulin Inhibitor H3 (ITIH3) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Inter Alpha-Globulin Inhibitor H3 (ITIH3) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Inter Alpha-Globulin Inhibitor H3 (ITIH3) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Inter Alpha-Globulin Inhibitor H3 (ITIH3) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Inter Alpha-Globulin Inhibitor H3 (ITIH3) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Inter Alpha-Globulin Inhibitor H3 (ITIH3) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Inter Alpha-Globulin Inhibitor H3 (ITIH3) | ELISA Kit Customized Service Offer |
- "Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence."Eur. J. Biochem. 212:771-776(1993) [PubMed] [Europe PMC] [Abstract]
- "Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage."J. Biol. Chem. 273:26809-26819(1998) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes."Biochim. Biophys. Acta 1219:551-554(1994) [PubMed] [Europe PMC] [Abstract]
- "Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan."J. Biol. Chem. 264:15975-15981(1989) [PubMed] [Europe PMC] [Abstract]
- "Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes."Eur. J. Biochem. 179:147-154(1989) [PubMed] [Europe PMC] [Abstract]
- "Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor."J. Biol. Chem. 266:747-751(1991) [PubMed] [Europe PMC] [Abstract]
- "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]