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Jun Dimerization Protein 2 (JDP2)

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JUNDM2; Progesterone Receptor Co-Activator

Jun Dimerization Protein 2 (JDP2)
CCC H768
HGNC 17546
MGI 1932093
PubMed 23200825
RGD 621611
UniProt Q8WYK2
Wiki JDP2
Jdp2 has an N-terminal domain, a central basic region-leucine zipper domain, and a C-terminal domain.mouse Jdp2 is an inhibitory subunit of the differentiation regulatory factor (DRF) complex. Jdp2 repressed retinoic acid-induced transcription of the Jun gene by recruiting a histone deacetylase-3 (HDAC3)-containing complex to the differentiation response element (DRE) of the Jun promoter.
Overexpression of mouse Jdp2 activated the promoters of Trap and cathepsin K (6001105) in a mouse hematopoietic progenitor cell line. Overexpression of Jdp2 also facilitated Rankl -mediated formation of Trap-positive multinuclear osteoclasts, and Jdp2 antisense oligonucleotides suppressed Rankl-induced osteoclast differentiation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Jun Dimerization Protein 2 (JDP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Jun Dimerization Protein 2 (JDP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Jun Dimerization Protein 2 (JDP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Jun Dimerization Protein 2 (JDP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Jun Dimerization Protein 2 (JDP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Jun Dimerization Protein 2 (JDP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Jun Dimerization Protein 2 (JDP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Jun Dimerization Protein 2 (JDP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Jun Dimerization Protein 2 (JDP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Jun Dimerization Protein 2 (JDP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Jun Dimerization Protein 2 (JDP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Jun Dimerization Protein 2 (JDP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Jun Dimerization Protein 2 (JDP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Jun Dimerization Protein 2 (JDP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Jun Dimerization Protein 2 (JDP2) ELISA Kit Customized Service Offer
  1. "Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL."J. Exp. Med. 197:1029-1035(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Transcriptional regulation of the c-jun gene by AP-1 repressor protein JDP2 during the differentiation of F9 cells."Nucleic Acids Res. Suppl. 2:97-98(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2."Nat. Struct. Mol. Biol. 13:331-338(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis."Biochim. Biophys. Acta 1745:29-37(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1."Anal. Biochem. 376:115-121(2008) [PubMed] [Europe PMC] [Abstract]
  8. "IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription."FEBS Lett. 582:2833-2837(2008) [PubMed] [Europe PMC] [Abstract]