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Kynurenine 3-monooxygenase (KMO; EC 1.14.13.9) is an NADPH-dependent flavin monooxygenase that catalyzes the hydroxylation of the L-tryptophan metabolite L-kynurenine to form L-3-hydroxykynurenine.
The predicted 486-amino acid human protein shares 47% sequence identity with Drosophila KMO. When expressed in mammalian cells, recombinant human KMO exhibited kinetic properties similar to those of the native human protein. Northern blot analysis revealed that human KMO is expressed as an approximately 2-kb mRNA in liver and placenta, and at lower levels in kidney.Expression of a mutant huntingtin (HTT) fragment in yeast, as in neurons, results in the formation of inclusion bodies and confers cellular toxicity.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPH755Hu01 | Recombinant Kynurenine-3-Monooxygenase (KMO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAH755Hu01 | Polyclonal Antibody to Kynurenine-3-Monooxygenase (KMO) | WB; IHC; ICC; IP. |
| MAH755Hu21 | Monoclonal Antibody to Kynurenine-3-Monooxygenase (KMO) | WB; IHC; ICC; IP. | |
| Assay Kits | SEH755Hu | ELISA Kit for Kynurenine-3-Monooxygenase (KMO) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Kynurenine-3-Monooxygenase (KMO) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Kynurenine-3-Monooxygenase (KMO) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Kynurenine-3-Monooxygenase (KMO) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Kynurenine-3-Monooxygenase (KMO) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Kynurenine-3-Monooxygenase (KMO) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPH755Ra01 | Recombinant Kynurenine-3-Monooxygenase (KMO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAH755Ra01 | Polyclonal Antibody to Kynurenine-3-Monooxygenase (KMO) | WB; IHC; ICC; IP. |
| MAH755Ra21 | Monoclonal Antibody to Kynurenine-3-Monooxygenase (KMO) | WB; IHC; ICC; IP. | |
| Assay Kits | SEH755Ra | ELISA Kit for Kynurenine-3-Monooxygenase (KMO) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Kynurenine-3-Monooxygenase (KMO) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Kynurenine-3-Monooxygenase (KMO) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Kynurenine-3-Monooxygenase (KMO) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEH755Rb | ELISA Kit for Kynurenine-3-Monooxygenase (KMO) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Cloning and functional expression of human kynurenine 3-monooxygenase."FEBS Lett. 410:407-412(1997) [PubMed] [Europe PMC] [Abstract].
- "Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase."Eur. J. Biochem. 267:1092-1099(2000) [PubMed] [Europe PMC] [Abstract]
- Ref.2"Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase."Eur. J. Biochem. 267:1092-1099(2000) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "Endogenous kynurenines as targets for drug discovery and development."Nat. Rev. Drug Discov. 1:609-620(2002) [PubMed] [Europe PMC] [Abstract]