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Kinetochore Associated Protein 1 (KNTC1)

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ROD; Rough Deal Homolog

Kinetochore Associated Protein 1 (KNTC1)
CCC H753
HGNC 17255
MGI 2673709
PubMed 19664251
UniProt P50748
KNTC1 is a homolog of the Drosophila 'rough deal' (Rod) protein, a component of the mitotic checkpoint surveillance mechanism. This complex prevents the onset of anaphase by elaborating an inhibitory signal until all chromosomes are properly attached and aligned on the spindle.
KNTC1 throughout the cytoplasm of cells at all mitotic stages. A fraction of the total pool was associated with kinetochores and the spindle during mitosis. KNTC1 initially concentrated at kinetochores during prometaphase. During metaphase, staining moved to the spindle fibers and prominently to the spindle poles. By late anaphase, KNTC1 was detected only at the spindle poles. KNTC1 colocalized with ZW10 at kinetochores at prometaphase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinetochore Associated Protein 1 (KNTC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinetochore Associated Protein 1 (KNTC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinetochore Associated Protein 1 (KNTC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinetochore Associated Protein 1 (KNTC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinetochore Associated Protein 1 (KNTC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinetochore Associated Protein 1 (KNTC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinetochore Associated Protein 1 (KNTC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinetochore Associated Protein 1 (KNTC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinetochore Associated Protein 1 (KNTC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinetochore Associated Protein 1 (KNTC1) ELISA Kit Customized Service Offer
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