Pro-Platelet Basic Protein Like Protein 2 (PPBPL2)

By screening an adult human lung cDNA library, Luzi and Strayer (1995) identified PPBPL2, which they called A2. The deduced protein contains 106 amino acids. By gel retardation assay, Luzi and Strayer (1995) demonstrated that PPBPL2 exhibited binding activity to a 212-bp region of the SPB (SFTPB) promoter and slightly increased transcription of a luciferase reporter containing the promoter region.

Beta-thromboglobulin (β-thromboglobulin, also called Pro-Platelet basic protein) is a protein that is stored in alpha-granules of platelets and released in large amounts after platelet activation.It is a chemoattractant, strongly for fibroblasts and weakly for neutrophils. It is a stimulator of mitogenesis, extracellular matrix synthesis, glucose metabolism, and plasminogen activator synthesis in human fibroblasts.