Leiomodin 1 (LMOD1)
[Edit]SM-Lmod; Smooth Muscle Leiomodin; 64 kDa autoantigen 1D; Thyroid-associated ophthalmopathy autoantigen
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The leiomodin 1 protein has a putative membrane-spanning region and 2 types of tandemly repeated blocks. The transcript is expressed in all tissues tested, with the highest levels in thyroid, eye muscle, skeletal muscle, and ovary. Increased expression of leiomodin 1 may be linked to Graves' disease and thyroid-associated ophthalmopathy.
LMOD1 is expressed as a 3.9-kb mRNA in normal thyroid and eye orbital muscle. The predicted 572-amino acid protein has a putative membrane-spanning region and 2 types of tandemly repeated blocks. Western blot analysis of thyroid tissue showed that the LMOD1 protein has a molecular mass of 64 kD. Sera from 8 of 34 patients with autoimmune thyroid disease contained antibodies to LMOD1; all 12 normal and nonautoimmune individuals were negative.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Leiomodin 1 (LMOD1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Leiomodin 1 (LMOD1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Leiomodin 1 (LMOD1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Leiomodin 1 (LMOD1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Leiomodin 1 (LMOD1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Leiomodin 1 (LMOD1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Leiomodin 1 (LMOD1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Leiomodin 1 (LMOD1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Leiomodin 1 (LMOD1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Leiomodin 1 (LMOD1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Leiomodin 1 (LMOD1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Leiomodin 1 (LMOD1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Leiomodin 1 (LMOD1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Leiomodin 1 (LMOD1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Leiomodin 1 (LMOD1) | ELISA Kit Customized Service Offer |
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- "Localization of the human 64kD autoantigen D1 to myofibrils in a subset of extraocular muscle fibers."Curr. Eye Res. 19:313-322(1999) [PubMed] [Europe PMC] [Abstract]
- "Leiomodin and tropomodulin in smooth muscle."Am. J. Physiol. 280:C1645-C1656(2001) [PubMed] [Europe PMC] [Abstract]
- "Leiomodins: larger members of the tropomodulin (Tmod) gene family."Genomics 73:127-139(2001) [PubMed] [Europe PMC] [Abstract]