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Lecithin Retinol Acyltransferase (LRAT)

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Phosphatidylcholine--Retinol O-Acyltransferase

Lecithin Retinol Acyltransferase (LRAT)
CCC H720
HGNC 6685
MGI 1891259
PubMed 14684738
RGD 68362
UniProt O95237
Wiki LRAT
Lecithin Retinol Acyltransferase is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy.
The predicted 230-amino acid human LRAT protein contains 2 putative transmembrane domains. Western blot analysis detected an approximately 25- to 26-kD LRAT protein in human RPE cells; the calculated molecular mass of LRAT is 25.3 kD. Northern blot analysis detected a major 5.0-kb LRAT transcript in several human tissues, particularly those known for their high vitamin A-processing activity. In fetal tissues, LRAT was expressed in the RPE and liver, and slightly in brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lecithin Retinol Acyltransferase (LRAT) Recombinant Protein Customized Service Offer
Antibodies PAH720Hu01 Polyclonal Antibody to Lecithin Retinol Acyltransferase (LRAT) WB; IHC; ICC; IP.
LAH720Hu71 Biotin-Linked Polyclonal Antibody to Lecithin Retinol Acyltransferase (LRAT) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Lecithin Retinol Acyltransferase (LRAT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lecithin Retinol Acyltransferase (LRAT) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lecithin Retinol Acyltransferase (LRAT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lecithin Retinol Acyltransferase (LRAT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lecithin Retinol Acyltransferase (LRAT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lecithin Retinol Acyltransferase (LRAT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lecithin Retinol Acyltransferase (LRAT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lecithin Retinol Acyltransferase (LRAT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lecithin Retinol Acyltransferase (LRAT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lecithin Retinol Acyltransferase (LRAT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lecithin Retinol Acyltransferase (LRAT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lecithin Retinol Acyltransferase (LRAT) ELISA Kit Customized Service Offer
  1. "Molecular and biochemical characterization of lecithin retinol acyltransferase."J. Biol. Chem. 274:3834-3841(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning, gene organization and identification of an alternative splicing process in lecithin:retinol acyltransferase cDNA from human liver."Gene 341:181-188(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Lecithin retinol acyltransferase contains cysteine residues essential for catalysis."Biochemistry 39:5215-5220(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of novel mutations in patients with Leber congenital amaurosis and juvenile RP by genome-wide homozygosity mapping with SNP microarrays."Invest. Ophthalmol. Vis. Sci. 48:5690-5698(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Lecithin: retinol acyltransferase protein is distributed in both hepatic stellate cells and endothelial cells of normal rodent and human liver."Liver Int. 29:47-54(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations in the gene encoding lecithin retinol acyltransferase are associated with early-onset severe retinal dystrophy."Nat. Genet. 28:123-124(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Screening genes of the retinoid metabolism: novel LRAT mutation in Leber congenital amaurosis."Am. J. Ophthalmol. 142:702-704(2006) [PubMed] [Europe PMC] [Abstract]