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Mannosidase Alpha Class 2B Member 1 (MAN2B1)

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MANB; LAMAN; Lysosomal alpha-mannosidase; Lysosomal acid alpha-mannosidase; Mannosidase alpha-B

Mannosidase Alpha Class 2B Member 1 (MAN2B1)
CCC H694
HGNC 6826
MGI 107286
PubMed 22161967
RGD 3039
UniProt O00754
MAN2B1 encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH694Hu01 Recombinant Mannosidase Alpha Class 2B Member 1 (MAN2B1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH694Hu21 Monoclonal Antibody to Mannosidase Alpha Class 2B Member 1 (MAN2B1) WB; IHC; ICC; IP.
PAH694Hu01 Polyclonal Antibody to Mannosidase Alpha Class 2B Member 1 (MAN2B1) WB; IHC; ICC; IP.
Assay Kits SEH694Hu ELISA Kit for Mannosidase Alpha Class 2B Member 1 (MAN2B1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mannosidase Alpha Class 2B Member 1 (MAN2B1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mannosidase Alpha Class 2B Member 1 (MAN2B1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mannosidase Alpha Class 2B Member 1 (MAN2B1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mannosidase Alpha Class 2B Member 1 (MAN2B1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mannosidase Alpha Class 2B Member 1 (MAN2B1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mannosidase Alpha Class 2B Member 1 (MAN2B1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mannosidase Alpha Class 2B Member 1 (MAN2B1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mannosidase Alpha Class 2B Member 1 (MAN2B1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mannosidase Alpha Class 2B Member 1 (MAN2B1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mannosidase Alpha Class 2B Member 1 (MAN2B1) ELISA Kit Customized Service Offer
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  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Missense and nonsense mutations in the lysosomal alpha-mannosidase gene (MANB) in severe and mild forms of alpha-mannosidosis."Am. J. Hum. Genet. 63:1015-1024(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Spectrum of mutations in alpha-mannosidosis."Am. J. Hum. Genet. 64:77-88(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Alpha-mannosidosis and mutational analysis in a Turkish patient."Turk. J. Pediatr. 45:46-50(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Identification and characterization of five novel MAN2B1 mutations in Italian patients with alpha-mannosidosis."Hum. Mutat. 25:320-320(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of 83 novel alpha-mannosidosis-associated sequence variants: functional analysis of MAN2B1 missense mutations."Hum. Mutat. 33:511-520(2012) [PubMed] [Europe PMC] [Abstract]