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Myristoylated Alanine Rich Protein Kinase C Substrate (MARCKS)

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80K-L; MACS; MRACKS; PKCSL; PRKCSL; Protein kinase C substrate, 80 kDa protein, light chain

Myristoylated Alanine Rich Protein Kinase C Substrate (MARCKS)
CCC H688
HGNC 6759
MGI 96907
PubMed 1560845
RGD 3028
UniProt P29966
Wiki MARCKS
MARCKS is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. MARCKS is a filamentous actin crosslinking protein, with activity that is inhibited by PKC-mediated phosphorylation and by binding to calcium-calmodulin. MARCKS may be a regulated crossbridge between actin and the plasma membrane, and modulation of the actin crosslinking activity of the MARCKS protein by calmodulin and phosphorylation represents a potential convergence of the calcium-calmodulin and protein kinase C signal transduction pathways in the regulation of the actin cytoskeleton.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH688Hu01 Recombinant Myristoylated Alanine Rich Protein Kinase C Substrate (MARCKS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH688Hu01 Polyclonal Antibody to Myristoylated Alanine Rich Protein Kinase C Substrate (MARCKS) WB; IHC; ICC; IP.
MAH688Hu21 Monoclonal Antibody to Myristoylated Alanine Rich Protein Kinase C Substrate (MARCKS) WB; IHC; ICC; IP.
Assay Kits SEH688Hu ELISA Kit for Myristoylated Alanine Rich Protein Kinase C Substrate (MARCKS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myristoylated Alanine Rich Protein Kinase C Substrate (MARCKS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myristoylated Alanine Rich Protein Kinase C Substrate (MARCKS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myristoylated Alanine Rich Protein Kinase C Substrate (MARCKS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myristoylated Alanine Rich Protein Kinase C Substrate (MARCKS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myristoylated Alanine Rich Protein Kinase C Substrate (MARCKS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH688Ra01 Recombinant Myristoylated Alanine Rich Protein Kinase C Substrate (MARCKS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH688Ra21 Monoclonal Antibody to Myristoylated Alanine Rich Protein Kinase C Substrate (MARCKS) WB; IHC; ICC; IP.
PAH688Ra01 Polyclonal Antibody to Myristoylated Alanine Rich Protein Kinase C Substrate (MARCKS) WB; IHC; ICC; IP.
Assay Kits SEH688Ra ELISA Kit for Myristoylated Alanine Rich Protein Kinase C Substrate (MARCKS) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The human myristoylated alanine-rich C kinase substrate (MARCKS) gene (MACS). Analysis of its gene product, promoter, and chromosomal localization."J. Biol. Chem. 266:14399-14405(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and chromosomal mapping of a cDNA encoding human 80K-L protein: major substrate for protein kinase C."Genomics 14:175-178(1992) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Relationship between the major protein kinase C substrates acidic 80-kDa protein-kinase-C substrate (80K) and myristoylated alanine-rich C-kinase substrate (MARCKS). Members of a gene family or equivalent genes in different species."Eur. J. Biochem. 209:7-14(1992) [PubMed] [Europe PMC] [Abstract]
  6. "PRK1 phosphorylates MARCKS at the PKC sites: serine 152, serine 156 and serine 163."FEBS Lett. 378:281-285(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]