MAP/Microtubule Affinity Regulating Kinase 1 (MARK1)
[Edit]Par1c; PAR1 homolog c; Serine/threonine-protein kinase MARK1
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The MARK1 gene encodes a kinase involved in the phosphorylation of microtubule-associated proteins. The microtubule array has a central role in the regulation of cell shape and polarity during differentiation, chromosome partitioning at mitosis, and intracellular transport. Microtubules undergo rearrangements involving rapid transitions between stable and dynamic states during these processes.
The 870-amino acid protein is 90% identical to the rat serine/threonine kinase Mark1. Within brain, highest levels were detected in hippocampus.The rat protein has 793 amino acids. Northern blot analysis with rat probes revealed expression of a 4.1-kb transcript with highest levels in heart and muscle.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant MAP/Microtubule Affinity Regulating Kinase 1 (MARK1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to MAP/Microtubule Affinity Regulating Kinase 1 (MARK1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to MAP/Microtubule Affinity Regulating Kinase 1 (MARK1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for MAP/Microtubule Affinity Regulating Kinase 1 (MARK1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for MAP/Microtubule Affinity Regulating Kinase 1 (MARK1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant MAP/Microtubule Affinity Regulating Kinase 1 (MARK1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to MAP/Microtubule Affinity Regulating Kinase 1 (MARK1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to MAP/Microtubule Affinity Regulating Kinase 1 (MARK1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for MAP/Microtubule Affinity Regulating Kinase 1 (MARK1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for MAP/Microtubule Affinity Regulating Kinase 1 (MARK1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant MAP/Microtubule Affinity Regulating Kinase 1 (MARK1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to MAP/Microtubule Affinity Regulating Kinase 1 (MARK1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to MAP/Microtubule Affinity Regulating Kinase 1 (MARK1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for MAP/Microtubule Affinity Regulating Kinase 1 (MARK1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for MAP/Microtubule Affinity Regulating Kinase 1 (MARK1) | ELISA Kit Customized Service Offer |
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- Ref.3"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "MARK - a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption."Cell 89:297-308(1997) [PubMed] [Europe PMC] [Abstract]
- "Microtubule-affinity regulating kinase (MARK) is tightly associated with neurofibrillary tangles in Alzheimer brain: a fluorescence resonance energy transfer study."J. Neuropathol. Exp. Neurol. 59:966-971(2000) [PubMed] [Europe PMC] [Abstract]
- "PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling."Nat. Cell Biol. 3:628-636(2001) [PubMed] [Europe PMC] [Abstract]
- "Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling."J. Biol. Chem. 282:23532-23540(2007) [PubMed] [Europe PMC] [Abstract]
- "Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism."Hum. Mol. Genet. 17:2541-2551(2008) [PubMed] [Europe PMC] [Abstract]
- "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
- "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
- "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
- "The tau of MARK: a polarized view of the cytoskeleton."Trends Biochem. Sci. 34:332-342(2009) [PubMed] [Europe PMC] [Abstract]
- "Structure and function of polarity-inducing kinase family MARK/Par-1 within the branch of AMPK/Snf1-related kinases."FASEB J. 24:1637-1648(2010) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
- "Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2."J. Biol. Chem. 281:27586-27599(2006) [PubMed] [Europe PMC] [Abstract]
- "Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids."Cell 143:966-977(2010) [PubMed] [Europe PMC] [Abstract]
- "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]