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Membrane Frizzled Related Protein (MFRP)

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NNO2; Rd6; C1QTNF5; Complement C1q Tumor Necrosis Factor-Related Protein 5 Precursor Variant 1

Membrane Frizzled Related Protein (MFRP)
CCC H658
HGNC 18121
MGI 2385957
PubMed 11263980
RGD 1307477
UniProt Q9BY79
Wiki MFRP
Katoh (2001) identified MFRP. Using PCR analysis, they obtained an MFRP cDNA sequence predicted to encode a 579-amino acid type II transmembrane protein with 2 MFRP domains, a CRD, and 2 cubilin (CUB) domains. Northern blot analysis detected a 4.0-kb MFRP transcript in adult and fetal brain. Expression was weak in hippocampus and corpus callosum and strong in medulla oblongata. MFRP may play key roles in medulla oblongata as a regulator of the WNT signaling pathway. CTRP5 encodes a short-chain collagen gene exclusively expressed in the retina, is contained within the 3-prime untranslated region of exon 13 of MFRP. CTRP5 is present in the same orientation as MFRP, and both genes are expressed as a bicistronic transcript.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Frizzled Related Protein (MFRP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Frizzled Related Protein (MFRP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Frizzled Related Protein (MFRP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Frizzled Related Protein (MFRP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Frizzled Related Protein (MFRP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Frizzled Related Protein (MFRP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Frizzled Related Protein (MFRP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Frizzled Related Protein (MFRP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Frizzled Related Protein (MFRP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Frizzled Related Protein (MFRP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Frizzled Related Protein (MFRP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Frizzled Related Protein (MFRP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Frizzled Related Protein (MFRP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Frizzled Related Protein (MFRP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Frizzled Related Protein (MFRP) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of MFRP, a novel gene encoding a membrane-type frizzled-related protein."Biochem. Biophys. Res. Commun. 282:116-123(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Sequencing arrays for screening multiple genes associated with early-onset human retinal degenerations on a high-throughput platform."Invest. Ophthalmol. Vis. Sci. 46:3355-3362(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Spatial and temporal expression of MFRP and its interaction with CTRP5."Invest. Ophthalmol. Vis. Sci. 47:5514-5521(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes."J. Dermatol. Sci. 42:111-119(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Mutation screen of the membrane-type frizzled-related protein (MFRP) gene in patients with inherited retinal degenerations."Ophthalmic Genet. 26:157-161(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Extreme hyperopia is the result of null mutations in MFRP, which encodes a frizzled-related protein."Proc. Natl. Acad. Sci. U.S.A. 102:9553-9558(2005) [PubMed] [Europe PMC] [Abstract]
  9. "A new autosomal recessive syndrome consisting of posterior microphthalmos, retinitis pigmentosa, foveoschisis, and optic disc drusen is caused by a MFRP gene mutation."Mol. Vis. 12:1483-1489(2006) [PubMed] [Europe PMC] [Abstract]