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Molybdenum Cofactor Sulfurase (MOCOS)

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MOS; HMCS; Molybdenum cofactor sulfurtransferase

Molybdenum Cofactor Sulfurase (MOCOS)
CCC H632
HGNC 18234
MGI 1915841
PubMed 11302742
RGD 1308496
UniProt Q96EN8
Wiki MOCOS
MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase (XDH) and aldehyde oxidase (AOX1), which is required for their enzymatic activities.
By searching an EST database for sequences similar to MOCOS orthologs in Aspergillus and Drosophila, followed by PCR of a liver cDNA library and database analysis, Ichida et al. (2001) obtained full-length human MOCOS, which they called HMCS. The deduced 888-amino acid protein contains a pyridoxal phosphate-binding site motif and has characteristics of an NifS (NFS1)-like protein. MOCOS shares about 30% identity with the Aspergillus and Drosophila proteins and about 80% identity with bovine Mocos.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Molybdenum Cofactor Sulfurase (MOCOS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Molybdenum Cofactor Sulfurase (MOCOS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Molybdenum Cofactor Sulfurase (MOCOS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Molybdenum Cofactor Sulfurase (MOCOS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Molybdenum Cofactor Sulfurase (MOCOS) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Molybdenum Cofactor Sulfurase (MOCOS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Molybdenum Cofactor Sulfurase (MOCOS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Molybdenum Cofactor Sulfurase (MOCOS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Molybdenum Cofactor Sulfurase (MOCOS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Molybdenum Cofactor Sulfurase (MOCOS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Molybdenum Cofactor Sulfurase (MOCOS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Molybdenum Cofactor Sulfurase (MOCOS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Molybdenum Cofactor Sulfurase (MOCOS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Molybdenum Cofactor Sulfurase (MOCOS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Molybdenum Cofactor Sulfurase (MOCOS) ELISA Kit Customized Service Offer
  1. "Mutation of human molybdenum cofactor sulfurase gene is responsible to classical xanthinuria type II."Biochem. Biophys. Res. Commun. 282:1194-1200(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of the missing component in the mitochondrial benzamidoxime prodrug converting system as a novel molybdenum enzyme."J. Biol. Chem. 281:34796-34802(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Classical xanthinuria type 2 associated with a missense mutation in HMCS, the gene encoding molybdenum cofactor sulfurase."(In) EUREGIO congress of clinical chemistry and laboratory medicine, pp.36-37, Aachen (2003)
  12. "Identification of a new point mutation in the human molybdenum cofactor sulferase gene that is responsible for xanthinuria type II."Metabolism 52:1501-1504(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Identification and characterization of the first mutation (Arg776Cys) in the C-terminal domain of the human molybdenum cofactor sulfurase (HMCS) associated with type II classical xanthinuria."Mol. Genet. Metab. 91:23-29(2007) [PubMed] [Europe PMC] [Abstract]