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M-Phase Phosphoprotein 10 (MPHOSPH10)

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MPP10; MPP10P; CT90; U3 Small Nucleolar Ribonucleoprotein

M-Phase Phosphoprotein 10 (MPHOSPH10)
CCC H621
HGNC 7213
MGI 1915223
PubMed 12655004
RGD 1307633
UniProt O00566
Wiki MPHOSPH10
MPHOSPH10 encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein is thought to be part of the U3 small nucleolar ribonucleoprotein complex, which is involved in rRNA processing.Sequence analysis predicted that the 681-amino acid protein has a PEST sequence and 6 coiled-coil alpha helices containing acidic and basic stretches found in many nucleolar proteins. Cell fractionation and immunoblot analysis confirmed the nuclear and nucleolar localization of MPHOSPH10. Detailed examination of different phases of the cell cycle by immunofluorescence microscopy showed that MPHOSPH10 colocalizes with fibrillarin and is a component of U3 small nucleolar ribonucleoproteins (snoRNPs).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant M-Phase Phosphoprotein 10 (MPHOSPH10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to M-Phase Phosphoprotein 10 (MPHOSPH10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to M-Phase Phosphoprotein 10 (MPHOSPH10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for M-Phase Phosphoprotein 10 (MPHOSPH10) CLIA Kit Customized Service Offer
n/a ELISA Kit for M-Phase Phosphoprotein 10 (MPHOSPH10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant M-Phase Phosphoprotein 10 (MPHOSPH10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to M-Phase Phosphoprotein 10 (MPHOSPH10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to M-Phase Phosphoprotein 10 (MPHOSPH10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for M-Phase Phosphoprotein 10 (MPHOSPH10) CLIA Kit Customized Service Offer
n/a ELISA Kit for M-Phase Phosphoprotein 10 (MPHOSPH10) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant M-Phase Phosphoprotein 10 (MPHOSPH10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to M-Phase Phosphoprotein 10 (MPHOSPH10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to M-Phase Phosphoprotein 10 (MPHOSPH10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for M-Phase Phosphoprotein 10 (MPHOSPH10) CLIA Kit Customized Service Offer
n/a ELISA Kit for M-Phase Phosphoprotein 10 (MPHOSPH10) ELISA Kit Customized Service Offer
  1. "Identification of novel M phase phosphoproteins by expression cloning."Mol. Biol. Cell 7:1455-1469(1996) [PubMed] [Europe PMC] [Abstract]
  2. "M phase phosphoprotein 10 is a human U3 small nucleolar ribonucleoprotein component."Mol. Biol. Cell 9:437-449(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Functional proteomic analysis of human nucleolus."Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes."Nucleic Acids Res. 31:1877-1887(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]