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Mesothelin (MSLN)

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SMR; MPF; CAK1; Pre-pro-megakaryocyte-potentiating factor; Megakaryocyte-potentiating factor

Mesothelin (MSLN)
CCC H615
HGNC 7371
MGI 1888992
PubMed 22412141
RGD 69333
UniProt Q13421
Wiki Mesothelin
Mesothelin is a 40kDa protein present on normal mesothelial cells and overexpressed in several human tumors, including mesothelioma and ovarian and pancreatic adenocarcinoma. The protein was first identified by its reactivity with monoclonal antibody K1. Subsequent cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF). Although it has been proposed that mesothelin may be involved in cell adhesion, its biological function is not known.Mesothelin is a tumour differentiation antigen that is normally present on the mesothelial cells lining the pleura, peritoneum and pericardium.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH615Hu01 Recombinant Mesothelin (MSLN) Positive Control; Immunogen; SDS-PAGE; WB.
RPH615Hu02 Recombinant Mesothelin (MSLN) Positive Control; Immunogen; SDS-PAGE; WB.
EPH615Hu61 Eukaryotic Mesothelin (MSLN) Positive Control; Immunogen; SDS-PAGE; WB.
APH615Hu61 Active Mesothelin (MSLN) Cell culture; Activity Assays.
Antibodies PAH615Hu01 Polyclonal Antibody to Mesothelin (MSLN) WB; IHC; ICC; IP.
MAH615Hu21 Monoclonal Antibody to Mesothelin (MSLN) WB
LAH615Hu71 Biotin-Linked Polyclonal Antibody to Mesothelin (MSLN) WB; IHC; ICC.
MAH615Hu22 Monoclonal Antibody to Mesothelin (MSLN) WB; IHC; ICC; IP.
MAH615Hu23 Monoclonal Antibody to Mesothelin (MSLN) WB
MAH615Hu25 Monoclonal Antibody to Mesothelin (MSLN) WB; IHC; ICC; IP.
MAH615Hu26 Monoclonal Antibody to Mesothelin (MSLN) WB; IHC; ICC; IP.
MAH615Hu27 Monoclonal Antibody to Mesothelin (MSLN) WB; IHC; ICC; IP.
MAH615Hu28 Monoclonal Antibody to Mesothelin (MSLN) WB; IHC; ICC; IP.
MAH615Hu24 Monoclonal Antibody to Mesothelin (MSLN) WB; IHC; ICC; IP.
MAH615Hu29 Monoclonal Antibody to Mesothelin (MSLN) WB; IHC; ICC; IP.
Assay Kits SEH615Hu ELISA Kit for Mesothelin (MSLN) Enzyme-linked immunosorbent assay for Antigen Detection.
AEH615Hu ELISA Kit for Anti-Mesothelin Antibody (Anti-MSLN) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH615Mu01 Recombinant Mesothelin (MSLN) Positive Control; Immunogen; SDS-PAGE; WB.
RPH615Mu02 Recombinant Mesothelin (MSLN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH615Mu01 Polyclonal Antibody to Mesothelin (MSLN) WB; IHC; ICC; IP.
PAH615Mu02 Polyclonal Antibody to Mesothelin (MSLN) WB; IHC; ICC; IP.
Assay Kits SEH615Mu ELISA Kit for Mesothelin (MSLN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mesothelin (MSLN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mesothelin (MSLN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mesothelin (MSLN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mesothelin (MSLN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mesothelin (MSLN) ELISA Kit Customized Service Offer
  1. "Molecular cloning and expression of megakaryocyte potentiating factor cDNA."J. Biol. Chem. 270:21984-21990(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers."Proc. Natl. Acad. Sci. U.S.A. 93:136-140(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of human mesothelin transcripts in ovarian and pancreatic cancer."BMC Cancer 4:19-19(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients."Clin. Cancer Res. 11:3814-3820(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A novel cytokine exhibiting megakaryocyte potentiating activity from a human pancreatic tumor cell line HPC-Y5."J. Biol. Chem. 269:805-808(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma."Proc. Natl. Acad. Sci. U.S.A. 96:11531-11536(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion."J. Biol. Chem. 279:9190-9198(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Megakaryocyte potentiation factor cleaved from mesothelin precursor is a useful tumor marker in the serum of patients with mesothelioma."Clin. Cancer Res. 12:4225-4231(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment."J. Proteome Res. 5:935-943(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Recognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights."J. Biol. Chem. 287:33123-33131(2012) [PubMed] [Europe PMC] [Abstract]