≡

Mevalonate Decarboxylase (MVD)

[Edit]

MPD; Mevalonate Pyrophosphate Decarboxylase; Diphosphomevalonate decarboxylase; Mevalonate (diphospho)decarboxylase

Mevalonate Decarboxylase (MVD)
CCC H602
HGNC 7529
MGI 2179327
PubMed 22203490
RGD 621292
UniProt P53602
Wiki MVD
The enzyme mevalonate pyrophosphate decarboxylase (MVD, EC 4.1.1.33) catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate. This unusual enzyme decarboxylates and dehydrates its substrate while hydrolyzing ATP. As a unique enzyme in one of the early steps in cholesterol biosynthesis, MVD may be a useful target for drugs aimed at lowering serum cholesterol levels.
Toth and Huwyler (1996) cloned the human MVD gene from a liver cDNA library. The cDNA encoded a 400-amino acid polypeptide. Northern blot analysis revealed a 2-kb mRNA present at similar levels in various human tissues. Expression studies indicated that the recombinant human enzyme is active as a 43-kD homodimer.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mevalonate Decarboxylase (MVD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mevalonate Decarboxylase (MVD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mevalonate Decarboxylase (MVD) Polyclonal Antibody Customized Service Offer
Assay Kits SEH602Hu ELISA Kit for Mevalonate Decarboxylase (MVD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mevalonate Decarboxylase (MVD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mevalonate Decarboxylase (MVD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mevalonate Decarboxylase (MVD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mevalonate Decarboxylase (MVD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mevalonate Decarboxylase (MVD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mevalonate Decarboxylase (MVD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mevalonate Decarboxylase (MVD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mevalonate Decarboxylase (MVD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mevalonate Decarboxylase (MVD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mevalonate Decarboxylase (MVD) ELISA Kit Customized Service Offer
  1. "Molecular cloning and expression of the cDNAs encoding human and yeast mevalonate pyrophosphate decarboxylase."J. Biol. Chem. 271:7895-7898(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways."J. Lipid Res. 38:2216-2223(1997) [PubMed] [Europe PMC] [Abstract]
  4. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure."Arch. Biochem. Biophys. 480:58-67(2008) [PubMed] [Europe PMC] [Abstract]