C-Myc Binding Protein 2 (MYCBP2)
[Edit]PAM; CMyc Binding 2; Probable E3 Ubiquitin-Protein Ligase; Protein Associates With Myc; Pam/highwire/rpm-1 protein; E3 ubiquitin-protein ligase MYCBP2
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The deduced 4,641-amino acid protein has a calculated molecular mass of 510 kD. PAM contains an N-terminal leucine zipper; 2 RCC1 homology domains (RHD1 and RHD2) separated by a basic region; a cell division sequence motif; 2 direct repeats of 91 amino acids (PAM repeats); a second leucine zipper; a serine-rich region that contains a domain homologous to histone-binding proteins, such as Xenopus N1/N2 (NASP); a putative nuclear localization signal; a potential ring zinc finger domain; and 2 putative C2H2-type zinc finger motifs.
Northern blot analysis detected highest expression of a 15-kb PAM transcript in brain and thymus. Expression was moderate in skeletal muscle, pancreas, and ovary and weak in all other tissues examined.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant C-Myc Binding Protein 2 (MYCBP2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to C-Myc Binding Protein 2 (MYCBP2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to C-Myc Binding Protein 2 (MYCBP2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for C-Myc Binding Protein 2 (MYCBP2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for C-Myc Binding Protein 2 (MYCBP2) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant C-Myc Binding Protein 2 (MYCBP2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to C-Myc Binding Protein 2 (MYCBP2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to C-Myc Binding Protein 2 (MYCBP2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for C-Myc Binding Protein 2 (MYCBP2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for C-Myc Binding Protein 2 (MYCBP2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant C-Myc Binding Protein 2 (MYCBP2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to C-Myc Binding Protein 2 (MYCBP2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to C-Myc Binding Protein 2 (MYCBP2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for C-Myc Binding Protein 2 (MYCBP2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for C-Myc Binding Protein 2 (MYCBP2) | ELISA Kit Customized Service Offer |
- "Identification of a large Myc-binding protein that contains RCC1-like repeats."Proc. Natl. Acad. Sci. U.S.A. 95:9172-9177(1998) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
- "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract].
- "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
- Ref.7"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
- "Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex."J. Biol. Chem. 279:1351-1358(2004) [PubMed] [Europe PMC] [Abstract]
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
- "Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling."Cell. Signal. 20:1084-1091(2008) [PubMed] [Europe PMC] [Abstract]
- "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
- "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
- "Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development."Mol. Cell. Biol. 29:3529-3543(2009) [PubMed] [Europe PMC] [Abstract]
- "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]