Neuralized Like Protein (NEURL)
[Edit]NEURL1; RNF67; h-neu; Neuralized Homolog; E3 ubiquitin-protein ligase NEURL1; RING finger protein 67
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The Drosophila 'neuralized' (neu) gene belongs to a group of genes involved in the determination of cell fate in the neurogenic region of the embryo. Mutations in neu, or in any of the other neurogenic genes, cause hyperplasia of primitive neural tissue. The predicted 557-amino acid protein, which they called NEU, is 30% and 32% identical to Drosophila and C. elegans neu, respectively. All 3 proteins contain 2 repeat units designated NHRs (neuralized homology repeats) and a RING finger domain near the C terminus.
Northern blot and RT-PCR analyses revealed that the 4.2-kb NEU mRNA is expressed in normal brain. However, NEU mRNA levels were very low in malignant astrocytoma tissues and in the majority of glioma cell lines examined.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Neuralized Like Protein (NEURL) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Neuralized Like Protein (NEURL) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Neuralized Like Protein (NEURL) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Neuralized Like Protein (NEURL) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Neuralized Like Protein (NEURL) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Neuralized Like Protein (NEURL) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Neuralized Like Protein (NEURL) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Neuralized Like Protein (NEURL) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Neuralized Like Protein (NEURL) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Neuralized Like Protein (NEURL) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Neuralized Like Protein (NEURL) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Neuralized Like Protein (NEURL) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Neuralized Like Protein (NEURL) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Neuralized Like Protein (NEURL) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Neuralized Like Protein (NEURL) | ELISA Kit Customized Service Offer |
- "Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region."Oncogene 16:1009-1019(1998) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland."Mol. Cell. Biol. 21:7481-7494(2001) [PubMed] [Europe PMC] [Abstract]
- "Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma."J. Neurooncol. 12:1244-1256(2010) [PubMed] [Europe PMC] [Abstract]