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Nicotinamide Nucleotide Transhydrogenase (NNT)

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Pyridine nucleotide transhydrogenase; (P) transhydrogenase, mitochondrial

Nicotinamide Nucleotide Transhydrogenase (NNT)
CCC H531
HGNC 7863
MGI 109279
PubMed 9271681
RGD 1587346
UniProt Q13423
Wiki NNT
NNT is a pyridine nucleotide transhydrogenase (EC 1.6.1.1). These integral inner mitochondrial membrane proteins are part of the energy-transfer system of the respiratory chain and catalyze the transfer of a hydride ion between nicotinamide adenine dinucleotide, NAD(H), and oxidized nicotinamide dinucleotide phosphate, NADP(H).
The deduced 1,086-amino acid NNT protein has a 43-amino acid presequence, 10 membrane-spanning alpha helices, and substrate-binding sites for NAD(H) and NADP(H). It shares 97% amino acid identity with bovine Nnt and 94% identity with mouse Nnt. A hypervariable region is located in the first transmembrane helix, and the presequences are less conserved.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nicotinamide Nucleotide Transhydrogenase (NNT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nicotinamide Nucleotide Transhydrogenase (NNT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nicotinamide Nucleotide Transhydrogenase (NNT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nicotinamide Nucleotide Transhydrogenase (NNT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nicotinamide Nucleotide Transhydrogenase (NNT) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nicotinamide Nucleotide Transhydrogenase (NNT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nicotinamide Nucleotide Transhydrogenase (NNT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nicotinamide Nucleotide Transhydrogenase (NNT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nicotinamide Nucleotide Transhydrogenase (NNT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nicotinamide Nucleotide Transhydrogenase (NNT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nicotinamide Nucleotide Transhydrogenase (NNT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nicotinamide Nucleotide Transhydrogenase (NNT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nicotinamide Nucleotide Transhydrogenase (NNT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nicotinamide Nucleotide Transhydrogenase (NNT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nicotinamide Nucleotide Transhydrogenase (NNT) ELISA Kit Customized Service Offer
  1. "Cloning and deduced amino acid sequence of human nicotinamide nucleotide transhydrogenase."DNA Seq. 7:369-374(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The cDNA sequence of proton-pumping nicotinamide nucleotide transhydrogenase from man and mouse."Biochim. Biophys. Acta 1273:203-205(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency."Nat. Genet. 44:740-742(2012) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "The high-resolution structure of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase from human heart mitochondria."Structure 8:1-12(2000) [PubMed] [Europe PMC] [Abstract]