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Neuronal PAS Domain Protein 2 (NPAS2)

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MOP4; PASD4; bHLHe9; Basic-helix-loop-helix-PAS protein MOP4; Class E basic helix-loop-helix protein 9; PAS domain-containing protein 4

Neuronal PAS Domain Protein 2 (NPAS2)
CCC H527
HGNC 7895
MGI 109232
PubMed 12446832
RGD 1309681
UniProt Q99743
Wiki NPAS2
Neuronal PAS Domain Protein 2 is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain.
The predicted 824-amino acid human NPAS2 protein shares 87% sequence identity with mouse Npas2. Northern blot analysis of mouse tissues revealed that Npas2 is expressed predominantly in brain. In situ hybridization indicated that the pattern of Npas2 mRNA distribution in mouse brain is broad and complex, and is largely nonoverlapping with that of Npas1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neuronal PAS Domain Protein 2 (NPAS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neuronal PAS Domain Protein 2 (NPAS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neuronal PAS Domain Protein 2 (NPAS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neuronal PAS Domain Protein 2 (NPAS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neuronal PAS Domain Protein 2 (NPAS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neuronal PAS Domain Protein 2 (NPAS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neuronal PAS Domain Protein 2 (NPAS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neuronal PAS Domain Protein 2 (NPAS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neuronal PAS Domain Protein 2 (NPAS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neuronal PAS Domain Protein 2 (NPAS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neuronal PAS Domain Protein 2 (NPAS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neuronal PAS Domain Protein 2 (NPAS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neuronal PAS Domain Protein 2 (NPAS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neuronal PAS Domain Protein 2 (NPAS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neuronal PAS Domain Protein 2 (NPAS2) ELISA Kit Customized Service Offer
  1. "Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system."Proc. Natl. Acad. Sci. U.S.A. 94:713-718(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway."J. Biol. Chem. 272:8581-8593(1997) [PubMed] [Europe PMC] [Abstract]
  5. "NPAS2: an analog of clock operative in the mammalian forebrain."Science 293:506-509(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors."Science 293:510-514(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Histone acetyltransferase-dependent chromatin remodeling and the vascular clock."J. Biol. Chem. 279:7091-7097(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood."Curr. Biol. 18:678-683(2008) [PubMed] [Europe PMC] [Abstract]
  9. "The circadian gene NPAS2, a putative tumor suppressor, is involved in DNA damage response."Mol. Cancer Res. 6:1461-1468(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Metabolism and the circadian clock converge."Physiol. Rev. 93:107-135(2013) [PubMed] [Europe PMC] [Abstract]
  11. "Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference."Neuropsychopharmacology 28:734-739(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma."Int. J. Cancer 120:432-435(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk."Breast Cancer Res. Treat. 107:421-425(2008) [PubMed] [Europe PMC] [Abstract]