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Nuclear Receptor Binding SET Domain Protein 1 (NSD1)

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STO; ARA267; KMT3B; Sotos Syndrome; Androgen receptor coactivator 267 kDa protein; Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific

Nuclear Receptor Binding SET Domain Protein 1 (NSD1)
CCC H517
HGNC 14234
MGI 1276545
PubMed 23592277
RGD 1307748
UniProt Q96L73
Wiki NSD1
NSD1 encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Receptor Binding SET Domain Protein 1 (NSD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Receptor Binding SET Domain Protein 1 (NSD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Receptor Binding SET Domain Protein 1 (NSD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Receptor Binding SET Domain Protein 1 (NSD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Receptor Binding SET Domain Protein 1 (NSD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Receptor Binding SET Domain Protein 1 (NSD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Receptor Binding SET Domain Protein 1 (NSD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Receptor Binding SET Domain Protein 1 (NSD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Receptor Binding SET Domain Protein 1 (NSD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Receptor Binding SET Domain Protein 1 (NSD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Receptor Binding SET Domain Protein 1 (NSD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Receptor Binding SET Domain Protein 1 (NSD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Receptor Binding SET Domain Protein 1 (NSD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Receptor Binding SET Domain Protein 1 (NSD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Receptor Binding SET Domain Protein 1 (NSD1) ELISA Kit Customized Service Offer
  1. "Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells."J. Biol. Chem. 276:40417-40423(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular characterization of NSD1, a human homologue of the mouse Nsd1 gene."Gene 279:197-204(2001) [PubMed] [Europe PMC] [Abstract]
  3. "A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia."Blood 98:1264-1267(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Haploinsufficiency of NSD1 causes Sotos syndrome." Nat. Genet. 30:365-366(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Paradoxical NSD1 mutations in Beckwith-Wiedemann syndrome and 11p15 anomalies in Sotos syndrome."Am. J. Hum. Genet. 74:715-720(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Cryptic insertion producing two NUP98/NSD1 chimeric transcripts in adult refractory anemia with an excess of blasts."Genes Chromosomes Cancer 41:395-399(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation."J. Biol. Chem. 286:8361-8368(2011) [PubMed] [Europe PMC] [Abstract]
  14. "NSD1 mutations are the major cause of Sotos syndrome and occur in some cases of Weaver syndrome but are rare in other overgrowth phenotypes."Am. J. Hum. Genet. 72:132-143(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Spectrum of NSD1 mutations in Sotos and Weaver syndromes."J. Med. Genet. 40:436-440(2003) [PubMed] [Europe PMC] [Abstract]
  16. "DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome." Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract]