Nucleoredoxin Like Protein 1 (NXNL1)

Rdcvf has 33% similarity to thioredoxin (TXN). The Rdcvf protein contains a potential N-glycosylation site and lacks a signal peptide sequence. The C terminus of Rdcvf interrupts the thioredoxin motif, and unlike other members of the thioredoxin family, Rdcvf did not have detectable oxidoreductase activity; however, an alternatively spliced form of Rdcvf mRNA results in a longer protein with a C terminal extension and could have oxidoreductase activity.

Rdcvf may be a bifunctional protein, with one extracellular form involved in cone viability and the other, with the extended C terminus, having oxidoreductase activity. Factors secreted from rods have been shown to be essential for cone viability.