![Oculomedin (OCLM)](/upload/item/img/Oculomedin-(OCLM)-97505.jpg)
Trabecular cells of the eye form a mesh-like structure called the trabecular meshwork, which is located at the iridocorneal angle. The trabecular meshwork is the main site of aqueous outflow. Studies have suggested that trabecular cells sense the intraocular pressure and respond by regulating aqueous outflow. One identified gene, which they named oculomedin, was expressed only in the stretched cells. The authors isolated a full-length oculomedin cDNA from a human eye cDNA library.
Northern blot analysis detected a 1.77-kb oculomedin transcript in human retina but not in other tissues, including brain. A segment of the deduced 44-amino acid oculomedin protein shares sequence similarity with a domain of rat neurokinin B precursor/neuromedin K ; this domain does not include the C-terminal motif conserved among tachykinin peptides.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Oculomedin (OCLM) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Oculomedin (OCLM) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Oculomedin (OCLM) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Oculomedin (OCLM) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Oculomedin (OCLM) | ELISA Kit Customized Service Offer |
- "A novel gene (oculomedin) induced by mechanical stretching in human trabecular cells of the eye."Biochem. Biophys. Res. Commun. 259:349-351(1999) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]