![Otopetrin 1 (OTOP1)](/upload/item/img/Otopetrin-1-(OTOP1)-97490.jpg)
Otoconia are biominerals within the utricle and saccule of the inner ear that are critical for the perception of gravity and linear acceleration. The classic mouse mutant 'tilted' (tlt) and the allelic mouse mutant 'mergulhador' (mlh) are recessive mutations that affect balance by impairing otoconial morphogenesis without causing collateral deafness. The predicted multitransmembrane domain protein is expressed in the macula of the developing otocyst of the inner ear as well as in thymus, heart, kidney, skin, stomach, adrenal gland, and lactating mammary gland. The deduced 612-amino acid protein shares 77% sequence identity with the mouse protein. Otop1 is detectable in murine macular sensory epithelia; its protein product, otopetrin, is incorporated into the gelatinous membrane within the utricle and saccule, along with otoconin.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Otopetrin 1 (OTOP1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Otopetrin 1 (OTOP1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Otopetrin 1 (OTOP1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Otopetrin 1 (OTOP1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Otopetrin 1 (OTOP1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Otopetrin 1 (OTOP1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Otopetrin 1 (OTOP1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Otopetrin 1 (OTOP1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Otopetrin 1 (OTOP1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Otopetrin 1 (OTOP1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Otopetrin 1 (OTOP1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Otopetrin 1 (OTOP1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Otopetrin 1 (OTOP1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Otopetrin 1 (OTOP1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Otopetrin 1 (OTOP1) | ELISA Kit Customized Service Offer |
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1."Hum. Mol. Genet. 12:777-789(2003) [PubMed] [Europe PMC] [Abstract]