![Otopetrin 2 (OTOP2)](/upload/item/img/Otopetrin-2-(OTOP2)-97489.jpg)
Otoconia are biominerals within the utricle and saccule of the inner ear that are critical for the perception of gravity and linear acceleration.
The classic mouse mutant 'tilted' (tlt) and the allelic mouse mutant 'mergulhador' (mlh) are recessive mutations that affect balance by impairing otoconial morphogenesis without causing collateral deafness. By database searching with the OTOP1 sequence as query, Hurle et al. (2003) identified 2 OTOP1-like genes, OTOP2 and OTOP3, in mouse and human.By genomic sequence analysis, Hurle et al. (2003) mapped the mouse Otop2 and Otop3 genes to chromosome 11q21 and both human homologs to a region of syntenic homology on chromosome 17q25.3.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Otopetrin 2 (OTOP2) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Otopetrin 2 (OTOP2) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Otopetrin 2 (OTOP2) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Otopetrin 2 (OTOP2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Otopetrin 2 (OTOP2) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Otopetrin 2 (OTOP2) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Otopetrin 2 (OTOP2) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Otopetrin 2 (OTOP2) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Otopetrin 2 (OTOP2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Otopetrin 2 (OTOP2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Otopetrin 2 (OTOP2) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Otopetrin 2 (OTOP2) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Otopetrin 2 (OTOP2) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Otopetrin 2 (OTOP2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Otopetrin 2 (OTOP2) | ELISA Kit Customized Service Offer |
- "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
- "Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1."Hum. Mol. Genet. 12:777-789(2003) [PubMed] [Europe PMC] [Abstract]
- "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]