≡

Phosphoribosylaminoimidazole Carboxylase (PAICS)

[Edit]

PAIS; ADE2H1; AIRC; Phosphoribosylaminoimidazole Succinocarboxamide Synthetase; AIR Carboxylase

Phosphoribosylaminoimidazole Carboxylase (PAICS)
CCC H471
HGNC 8587
MGI 1914304
PubMed 10574791
RGD 620066
UniProt P22234
Wiki PAICS
PAICS is an enzyme involved in nucleotide synthesis. It catalyzes the conversion of 5'-phosphoribosyl-5-aminoimidazole ("AIR") into 5-phosphoribosyl-4-carboxy-5-aminoimidazole ("CAIR"). PurK, N5-carboxyaminoimidazole ribonucleotide (N5_CAIR) synthetase, catalyzes the conversion of 5-aminoimidazole ribonucleotide (AIR), ATP, and bicarbonate to N5-CAIR, ADP, and Pi.PurE converts N5-CAIR to CAIR, the sixth step of de novo purine biosynthesis. In the presence of high concentrations of bicarbonate, PurE is reported able to convert AIR to CAIR directly and without ATP. Some members of this family contain two copies of this domain.Phosphoribosylaminoimidazole carboxylase is a fusion protein in plants and fungi, but consists of two non-interacting proteins in bacteria, PurK and PurE.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoribosylaminoimidazole Carboxylase (PAICS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoribosylaminoimidazole Carboxylase (PAICS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoribosylaminoimidazole Carboxylase (PAICS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoribosylaminoimidazole Carboxylase (PAICS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoribosylaminoimidazole Carboxylase (PAICS) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoribosylaminoimidazole Carboxylase (PAICS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoribosylaminoimidazole Carboxylase (PAICS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoribosylaminoimidazole Carboxylase (PAICS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoribosylaminoimidazole Carboxylase (PAICS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoribosylaminoimidazole Carboxylase (PAICS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoribosylaminoimidazole Carboxylase (PAICS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoribosylaminoimidazole Carboxylase (PAICS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoribosylaminoimidazole Carboxylase (PAICS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoribosylaminoimidazole Carboxylase (PAICS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoribosylaminoimidazole Carboxylase (PAICS) ELISA Kit Customized Service Offer
  1. "Cloning and sequencing of a human cDNA coding for a multifunctional polypeptide of the purine pathway by complementation of the ade2-101 mutant in Saccharomyces cerevisiae."Curr. Genet. 18:287-291(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. , Submitted (JUL-2004) to UniProtKB
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis."J. Mol. Biol. 366:1603-1614(2007) [PubMed] [Europe PMC] [Abstract]