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p21 Protein Activated Kinase 7 (PAK7)

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PAK5; Serine/threonine-protein kinase PAK 7

p21 Protein Activated Kinase 7 (PAK7)
CCC H467
HGNC 15916
MGI 1920334
PubMed 11756552
RGD 1312009
UniProt Q9P286
Wiki PAK7
PAK7 is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant p21 Protein Activated Kinase 7 (PAK7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to p21 Protein Activated Kinase 7 (PAK7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to p21 Protein Activated Kinase 7 (PAK7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for p21 Protein Activated Kinase 7 (PAK7) CLIA Kit Customized Service Offer
n/a ELISA Kit for p21 Protein Activated Kinase 7 (PAK7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant p21 Protein Activated Kinase 7 (PAK7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to p21 Protein Activated Kinase 7 (PAK7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to p21 Protein Activated Kinase 7 (PAK7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for p21 Protein Activated Kinase 7 (PAK7) CLIA Kit Customized Service Offer
n/a ELISA Kit for p21 Protein Activated Kinase 7 (PAK7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant p21 Protein Activated Kinase 7 (PAK7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to p21 Protein Activated Kinase 7 (PAK7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to p21 Protein Activated Kinase 7 (PAK7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for p21 Protein Activated Kinase 7 (PAK7) CLIA Kit Customized Service Offer
n/a ELISA Kit for p21 Protein Activated Kinase 7 (PAK7) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain."Oncogene 21:3939-3948(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of an autoinhibitory domain of p21-activated protein kinase 5."J. Biol. Chem. 278:33621-33624(2003) [PubMed] [Europe PMC] [Abstract]
  6. "p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD."Mol. Cell. Biol. 23:5526-5539(2003) [PubMed] [Europe PMC] [Abstract]
  7. "PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin."Mol. Biol. Cell 16:4410-4422(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Multiple Rho proteins regulate the subcellular targeting of PAK5."Biochem. Biophys. Res. Commun. 351:328-335(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties."Mol. Cell. Biol. 26:3215-3230(2006) [PubMed] [Europe PMC] [Abstract]
  10. "p21 activated kinase 5 activates Raf-1 and targets it to mitochondria."J. Cell. Biochem. 105:167-175(2008) [PubMed] [Europe PMC] [Abstract]
  11. "p120-catenin is a binding partner and substrate for Group B Pak kinases."J. Cell. Biochem. 110:1244-1254(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs."Structure 15:201-213(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]