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Poly A Polymerase Gamma (PAPOLg)

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Neo-PAP; Neo-poly(A) polymerase; Polynucleotide adenylyltransferase gamma; SRP RNA 3'-adenylating enzyme

Poly A Polymerase Gamma (PAPOLg)
CCC H459
HGNC 14982
MGI 2442119
PubMed 23964055
RGD 1310337
UniProt Q9BWT3
Wiki PAPOLG
Poly(A) polymerase gamma is a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains.
This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Poly A Polymerase Gamma (PAPOLg) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Poly A Polymerase Gamma (PAPOLg) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Poly A Polymerase Gamma (PAPOLg) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Poly A Polymerase Gamma (PAPOLg) CLIA Kit Customized Service Offer
n/a ELISA Kit for Poly A Polymerase Gamma (PAPOLg) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Poly A Polymerase Gamma (PAPOLg) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Poly A Polymerase Gamma (PAPOLg) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Poly A Polymerase Gamma (PAPOLg) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Poly A Polymerase Gamma (PAPOLg) CLIA Kit Customized Service Offer
n/a ELISA Kit for Poly A Polymerase Gamma (PAPOLg) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Poly A Polymerase Gamma (PAPOLg) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Poly A Polymerase Gamma (PAPOLg) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Poly A Polymerase Gamma (PAPOLg) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Poly A Polymerase Gamma (PAPOLg) CLIA Kit Customized Service Offer
n/a ELISA Kit for Poly A Polymerase Gamma (PAPOLg) ELISA Kit Customized Service Offer
  1. "Purification, characterization, and cloning of the cDNA of human signal recognition particle RNA 3'-adenylating enzyme."J. Biol. Chem. 276:21791-21796(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and functional characterization of neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumors."Mol. Cell. Biol. 21:5614-5623(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of human poly(A) polymerase gamma reveals a conserved catalytic core for canonical poly(A) polymerases."J. Mol. Biol. 426:43-50(2014) [PubMed] [Europe PMC] [Abstract]