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Paired Box Gene 8 (PAX8)

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Paired Box Gene 8 (PAX8)
CCC H448
HGNC 8622
MGI 97492
PubMed 21552115
RGD 620434
UniProt Q06710
Wiki PAX8
PAX8 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins which contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes.
The cell system they used provided direct evidence for the ability of PAX8 to activate transcription of thyroid-specific genes at their chromosomal locus and strongly suggested a fundamental role of this transcription factor in the maintenance of functional differentiation in thyroid cells. Moreover, they showed that PAX8 and thyroid transcription factor-1 (TITF1), which is encoded by the NKX2-1 gene, cooperate in the activation of the thyroglobulin promoter.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH448Hu01 Recombinant Paired Box Gene 8 (PAX8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH448Hu01 Polyclonal Antibody to Paired Box Gene 8 (PAX8) WB; IHC; ICC; IP.
Assay Kits SEH448Hu ELISA Kit for Paired Box Gene 8 (PAX8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Paired Box Gene 8 (PAX8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Paired Box Gene 8 (PAX8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Paired Box Gene 8 (PAX8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Paired Box Gene 8 (PAX8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paired Box Gene 8 (PAX8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Paired Box Gene 8 (PAX8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Paired Box Gene 8 (PAX8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Paired Box Gene 8 (PAX8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Paired Box Gene 8 (PAX8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paired Box Gene 8 (PAX8) ELISA Kit Customized Service Offer
  1. "PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors."Development 116:611-623(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties."Mol. Cell. Biol. 13:6024-6035(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Distinct functional properties of three human paired-box-protein, PAX8, isoforms generated by alternative splicing in thyroid, kidney and Wilms' tumors."Eur. J. Biochem. 228:899-911(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation."Exp. Cell Res. 315:162-175(2009) [PubMed] [Europe PMC] [Abstract]
  8. "PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis."Nat. Genet. 19:83-86(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Autosomal dominant transmission of congenital thyroid hypoplasia due to loss-of-function mutation of PAX8."J. Clin. Endocrinol. Metab. 86:234-238(2001) [PubMed] [Europe PMC] [Abstract]
  10. "A novel mutation (Q40P) in PAX8 associated with congenital hypothyroidism and thyroid hypoplasia: evidence for phenotypic variability in mother and child."J. Clin. Endocrinol. Metab. 86:3962-3967(2001) [PubMed] [Europe PMC] [Abstract]