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Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2)

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G17; HOX12; PBX2MHC; Pre-B-Cell Leukemia Transcription Factor 2

Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2)
CCC H432
HGNC 8633
MGI 1341793
PubMed 23400877
RGD 1303084
UniProt P40425
Wiki PBX2
PBX2 encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6. The predicted PBX2 and PBX3 proteins were 92 and 94% identical to PBX1 over a large region of 266 amino acids within and flanking their homeodomains, but all 3 proteins diverged significantly near their amino and carboxy termini. Like PBX1 RNA, PBX3 RNA is alternatively spliced to yield 2 translation products with different carboxy termini, a feature not observed for PBX2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2) ELISA Kit Customized Service Offer
  1. "PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1."Mol. Cell. Biol. 11:6149-6157(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein."Genomics 25:650-659(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3."Genomics 23:408-419(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation."Mol. Cell. Biol. 14:3938-3948(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA."J. Biol. Chem. 275:26172-26177(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene."Blood 101:4748-4756(2003) [PubMed] [Europe PMC] [Abstract]
  10. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]