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Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1)

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PRL; Pre-B-Cell Leukemia Transcription Factor 1

Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1)
CCC H431
HGNC 8632
MGI 97495
PubMed 21597276
RGD 1308213
UniProt P40424
Wiki PBX1
Human pre-B-cell acute lymphoblastic leukemias are frequently associated with a t(1;19)(q23;p13.3) chromosomal rearrangement. Kamps et al. (1990) and Nourse et al. (1990) demonstrated that several cell lines carrying this translocation synthesize chimeric mRNAs with 5-prime sequences encoded by the E2A transcription factor gene on chromosome 19 and 3-prime sequences encoded by a homeobox-related sequence, called Prl or PBX1, on chromosome 1.
In the chimeric transcription factor, the DNA binding domain of E2A is replaced by a putative DNA binding domain of PBX1. In 3 cell lines reported by Nourse et al. (1990), identical E2A-Prl mRNA junctions were observed, suggesting that the fusion transcripts are a consistent feature of this translocation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) ELISA Kit Customized Service Offer
  1. "PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1."Mol. Cell. Biol. 11:6149-6157(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Analysis of PBX1 as a candidate gene for type 2 diabetes mellitus in Pima Indians."Biochim. Biophys. Acta 1518:215-220(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL."Cell 60:547-555(1990) [PubMed] [Europe PMC] [Abstract]
  7. "The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias."Blood 77:687-693(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia."Proc. Natl. Acad. Sci. U.S.A. 90:6061-6065(1993) [PubMed] [Europe PMC] [Abstract]
  9. "Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation."Mol. Cell. Biol. 14:3938-3948(1994) [PubMed] [Europe PMC] [Abstract]
  10. "Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA."J. Biol. Chem. 275:26172-26177(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene."Blood 101:4748-4756(2003) [PubMed] [Europe PMC] [Abstract]
  12. "An autoinhibitory effect of the homothorax domain of Meis2."FEBS J. 277:2584-2597(2010) [PubMed] [Europe PMC] [Abstract]
  13. "MEIS proteins as partners of the TLX1/HOX11 oncoprotein."Leuk. Res. 34:358-363(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Cooperative transcriptional activation by Klf4, Meis2, and Pbx1."Mol. Cell. Biol. 31:3723-3733(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation."Cell 96:587-597(1999) [PubMed] [Europe PMC] [Abstract]