Phosphatidylinositol Glycan W (PIGW)
[Edit]Gwt1; Phosphatidylinositol Glycan Anchor Biosynthesis,Class W
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Glycosylphosphatidylinositol (GPI) is a complex glycolipid that anchors many proteins to the cell surface. PIGW acts in the third step of GPI biosynthesis and acylates the inositol ring of phosphatidylinositol.
By database searching for sequences similar to rat Pigw, Murakami et al. (2003) identified human PIGW. The deduced 504-amino acid protein contains 13 transmembrane domains and shares 77% sequence identity with the rat protein. Fractionation of a human lymphoblastoid cell line revealed that PIGW associated with the endoplasmic reticulum (ER). Murakami et al. (2003) determined that the N terminus and several conserved regions of rat Pigw face the lumen of the ER, whereas its C terminus is cytoplasmic.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Phosphatidylinositol Glycan W (PIGW) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Phosphatidylinositol Glycan W (PIGW) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Phosphatidylinositol Glycan W (PIGW) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Phosphatidylinositol Glycan W (PIGW) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Phosphatidylinositol Glycan W (PIGW) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Phosphatidylinositol Glycan W (PIGW) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Phosphatidylinositol Glycan W (PIGW) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Phosphatidylinositol Glycan W (PIGW) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Phosphatidylinositol Glycan W (PIGW) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Phosphatidylinositol Glycan W (PIGW) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Phosphatidylinositol Glycan W (PIGW) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Phosphatidylinositol Glycan W (PIGW) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Phosphatidylinositol Glycan W (PIGW) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Phosphatidylinositol Glycan W (PIGW) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Phosphatidylinositol Glycan W (PIGW) | ELISA Kit Customized Service Offer |
- "PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor."Mol. Biol. Cell 14:4285-4295(2003) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "Glycosylphosphatidylinositol (GPI) anchor deficiency caused by mutations in PIGW is associated with West syndrome and hyperphosphatasia with mental retardation syndrome."J. Med. Genet. 51:203-207(2014) [PubMed] [Europe PMC] [Abstract]