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Phosphatidylinositol Glycan V (PIGV)

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GPI-MT-II; phosphatidylinositol glycan anchor biosynthesis, class V; GPI mannosyltransferase 2

Phosphatidylinositol Glycan V (PIGV)
CCC H407
HGNC 26031
MGI 2442480
PubMed 20802478
RGD 1309526
UniProt Q9NUD9
Wiki PIGV
Glycosylphosphatidylinositol (GPI) is a complex glycolipid that anchors many proteins to the cell surface. The biosynthetic pathway of GPI is mediated by sequential addition of sugars and other components to phosphatidylinositol. PIGV adds the second mannose to the GPI core (Kang et al., 2005).
By database searching for sequences similar to rat Pigv, Kang et al. (2005) identified human PIGV. The deduced 493-amino acid protein has 8 putative transmembrane domains and shares 85% sequence identity with the rat protein. Fractionation of a human lymphoblastoid cell line revealed that PIGV associated with the endoplasmic reticulum (ER). Kang et al. (2005) determined that the N terminus and 2 conserved regions face the ER lumen.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol Glycan V (PIGV) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol Glycan V (PIGV) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol Glycan V (PIGV) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol Glycan V (PIGV) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol Glycan V (PIGV) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol Glycan V (PIGV) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol Glycan V (PIGV) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol Glycan V (PIGV) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol Glycan V (PIGV) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol Glycan V (PIGV) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol Glycan V (PIGV) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol Glycan V (PIGV) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol Glycan V (PIGV) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol Glycan V (PIGV) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol Glycan V (PIGV) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Familial hyperphosphatase with mental retardation, seizures, and neurologic deficits."J. Pediatr. 77:74-85(1970) [PubMed] [Europe PMC] [Abstract]
  5. "Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly."FEBS J. 272:1160-1168(2005) [PubMed] [Europe PMC] [Abstract]
  6. "PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol."J. Biol. Chem. 280:9489-9497(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Hyperphosphatasia with seizures, neurologic deficit, and characteristic facial features: Five new patients with Mabry syndrome."Am. J. Med. Genet. A 152:1661-1669(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Identity-by-descent filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrome." Nat. Genet. 42:827-829(2010) [PubMed] [Europe PMC] [Abstract]