Phosphatidylinositol Glycan U (PIGU)
[Edit]CDC91L1; GAB1; Phosphatidylinositol Glycan Anchor Biosynthesis,Class U; Cell Division Cycle 91,S. Cerevisiae,Homolog-Like 1; GPI transamidase component PIG-U
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Many eukaryotic proteins are anchored to the cell surface via glycosylphosphatidylinositol (GPI), which is posttranslationally attached to their C termini by GPI transamidase at the endoplasmic reticulum. PIGU is a critical subunit of mammalian GPI transamidase.
The deduced 435-amino acid protein contains 9 putative transmembrane domains and shares 97% identity with rat Pigu. SDS/PAGE analysis demonstrated that PIGU has an apparent molecular mass of 38 kD.CDC91L1 was amplified and overexpressed in about one-third of bladder cancer cell lines and primary tumors examined, as well as in oncogenic uroepithelial cells transformed with human papillomavirus E7.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Phosphatidylinositol Glycan U (PIGU) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Phosphatidylinositol Glycan U (PIGU) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Phosphatidylinositol Glycan U (PIGU) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Phosphatidylinositol Glycan U (PIGU) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Phosphatidylinositol Glycan U (PIGU) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Phosphatidylinositol Glycan U (PIGU) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Phosphatidylinositol Glycan U (PIGU) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Phosphatidylinositol Glycan U (PIGU) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Phosphatidylinositol Glycan U (PIGU) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Phosphatidylinositol Glycan U (PIGU) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Phosphatidylinositol Glycan U (PIGU) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Phosphatidylinositol Glycan U (PIGU) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Phosphatidylinositol Glycan U (PIGU) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Phosphatidylinositol Glycan U (PIGU) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Phosphatidylinositol Glycan U (PIGU) | ELISA Kit Customized Service Offer |
- "Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins."Mol. Biol. Cell 14:1780-1789(2003) [PubMed] [Europe PMC] [Abstract]
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- "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]