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Phosphatidylinositol Glycan A (PIGA)

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GPI3; Phosphatidylinositol Glycan Anchor Biosynthesis,Class A; Paroxysmal Nocturnal Hemoglobinuria; Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

Phosphatidylinositol Glycan A (PIGA)
CCC H393
HGNC 8957
MGI 99461
PubMed 8500164
RGD 1589723
UniProt P37287
Wiki PIGA
PIGA encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized.
Many cell surface proteins are anchored to the membrane by a glycolipid termed the glycosylphosphatidylinositol (GPI) anchor, which is covalently attached to the C-terminus of the peptide. The core of the GPI anchor consists of multiple components and its biosynthesis involves multiple genes, such as those for glycosyltransferases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol Glycan A (PIGA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol Glycan A (PIGA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol Glycan A (PIGA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol Glycan A (PIGA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol Glycan A (PIGA) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol Glycan A (PIGA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol Glycan A (PIGA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol Glycan A (PIGA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol Glycan A (PIGA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol Glycan A (PIGA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol Glycan A (PIGA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol Glycan A (PIGA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol Glycan A (PIGA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol Glycan A (PIGA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol Glycan A (PIGA) ELISA Kit Customized Service Offer
  1. "The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis."Science 259:1318-1320(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization of the X-linked gene (PIG-A) that is mutated in paroxysmal nocturnal haemoglobinuria and of a related autosomal pseudogene mapped to 12q21."Hum. Mol. Genet. 3:751-757(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of genomic PIG-A gene: a gene for glycosylphosphatidylinositol-anchor biosynthesis and paroxysmal nocturnal hemoglobinuria."Blood 83:3126-3131(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of alternatively spliced PIG-A transcripts in normal and paroxysmal nocturnal hemoglobinuria cells."Braz. J. Med. Biol. Res. 27:195-201(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria."Cell 73:703-711(1993) [PubMed] [Europe PMC] [Abstract]
  9. "The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component."Mol. Biol. Cell 16:5236-5246(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "The phenotype of a germline mutation in PIGA: the gene somatically mutated in paroxysmal nocturnal hemoglobinuria."Am. J. Hum. Genet. 90:295-300(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene."EMBO J. 13:110-117(1994) [PubMed] [Europe PMC] [Abstract]
  13. "Mutations within the Piga gene in patients with paroxysmal nocturnal hemoglobinuria."Blood 83:2418-2422(1994) [PubMed] [Europe PMC] [Abstract]
  14. "The spectrum of somatic mutations in the PIG-A gene in paroxysmal nocturnal hemoglobinuria includes large deletions and small duplications."Blood Cells Mol. Dis. 24:370-384(1998) [PubMed] [Europe PMC] [Abstract]
  15. "Mutation analysis of the PIG-A gene in Korean patients with paroxysmal nocturnal haemoglobinuria."J. Clin. Pathol. 55:410-413(2002) [PubMed] [Europe PMC] [Abstract]
  16. "A novel germline PIGA mutation in Ferro-Cerebro-Cutaneous syndrome: a neurodegenerative X-linked epileptic encephalopathy with systemic iron-overload."Am. J. Med. Genet. A 164A:17-28(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Expanding the spectrum of phenotypes associated with germline PIGA mutations: a child with developmental delay, accelerated linear growth, facial dysmorphisms, elevated alkaline phosphatase, and progressive CNS abnormalities."Am. J. Med. Genet. A 164A:29-35(2014) [PubMed] [Europe PMC] [Abstract]
  18. "PIGA mutations cause early-onset epileptic encephalopathies and distinctive features."Neurology 82:1587-1596(2014) [PubMed] [Europe PMC] [Abstract]