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Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1)

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MYT1; Membrane-Associated Tyrosine-And Threonine-Specific Cdc2-Inhibitory Kinase

Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1)
CCC H383
HGNC 29650
MGI 2137630
PubMed 11169965
RGD 1305434
UniProt Q99640
Wiki PKMYT1
PKMYT1 is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
The MYT1 cDNA encodes a predicted 499-amino acid polypeptide with a molecular mass of 55 kD. localizes to the endoplasmic reticulum and Golgi complex in HeLa cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) ELISA Kit Customized Service Offer
  1. "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity."J. Biol. Chem. 272:22300-22306(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex."Mol. Cell. Biol. 17:571-583(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins."Genes Dev. 12:706-720(1998) [PubMed] [Europe PMC] [Abstract]
  7. "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression."J. Cell Sci. 112:3361-3371(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes."Mol. Cell. Biol. 19:5113-5123(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate."J. Biol. Chem. 278:25277-25280(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]