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PHD Finger Protein 8 (PHF8)

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ZNF422; MRXSSD; JHDM1F; Jumonji C Domain-Containing Histone Demethylase 1F; Histone lysine demethylase PHF8

PHD Finger Protein 8 (PHF8)
CCC H375
HGNC 20672
MGI 2444341
PubMed 19843542
UniProt Q9UPP1
Wiki PHF8
PHF8 belongs to the family of ferrous iron and 2-oxoglutarate dependent oxygenases, and is active as a histone lysine demethylase with selectivity for the di-and monomethyl states.
Mutations in PHF8 cause Siderius type X-linked mental retardation (XLMR). In addition to moderate mental retardation, features of the Siderius-Hamel syndrome include facial dysmorphism, cleft lip and/or cleft palate, and in some cases microcephaly. A chromosomal microdeletion on Xp11.22 encompassing all of the PHF8 and FAM120C genes and a part of the WNK3 gene was reported in two brothers with autism spectrum disorder in addition to Siderius-type XLMR and cleft lip and palate.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PHD Finger Protein 8 (PHF8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PHD Finger Protein 8 (PHF8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PHD Finger Protein 8 (PHF8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PHD Finger Protein 8 (PHF8) CLIA Kit Customized Service Offer
n/a ELISA Kit for PHD Finger Protein 8 (PHF8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH375Mu01 Recombinant PHD Finger Protein 8 (PHF8) Positive Control; Immunogen; SDS-PAGE; WB.
RPH375Mu02 Recombinant PHD Finger Protein 8 (PHF8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH375Mu01 Polyclonal Antibody to PHD Finger Protein 8 (PHF8) WB; IHC; ICC; IP.
PAH375Mu02 Polyclonal Antibody to PHD Finger Protein 8 (PHF8) WB; IHC; ICC; IP.
Assay Kits SEH375Mu ELISA Kit for PHD Finger Protein 8 (PHF8) Enzyme-linked immunosorbent assay for Antigen Detection.
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