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Pleiotropic Regulator 1 (PLRG1)

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PRL1; Prp46; PRPF46; PRL1, Arabidopsis Homolog

Pleiotropic Regulator 1 (PLRG1)
CCC H367
HGNC 9089
MGI 1858197
PubMed 20467437
RGD 621047
UniProt O43660
Wiki PLRG1
By searching databases for sequences similar to the Arabidopsis pleiotropic regulator locus-1 (Prl1) gene, Nemeth et al. (1998) identified a cDNA encoding the human ortholog, PLRG1.
The deduced 514-amino acid basically charged protein, which is 59% identical to the plant sequence, contains multiple C-terminal WD40 repeats. Immunofluorescence microscopy demonstrated expression in green monkey cell nuclei. Immunoblot analysis indicated that PLRG1 interacts with the C terminus of the beta II isoform of protein kinase C, but not with its beta I isoform or with protein kinase C-gamma (PRKCG).The International Radiation Hybrid Mapping Consortium mapped the PLRG1 gene to chromosome 4.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pleiotropic Regulator 1 (PLRG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pleiotropic Regulator 1 (PLRG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pleiotropic Regulator 1 (PLRG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pleiotropic Regulator 1 (PLRG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pleiotropic Regulator 1 (PLRG1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pleiotropic Regulator 1 (PLRG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pleiotropic Regulator 1 (PLRG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pleiotropic Regulator 1 (PLRG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pleiotropic Regulator 1 (PLRG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pleiotropic Regulator 1 (PLRG1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pleiotropic Regulator 1 (PLRG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pleiotropic Regulator 1 (PLRG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pleiotropic Regulator 1 (PLRG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pleiotropic Regulator 1 (PLRG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pleiotropic Regulator 1 (PLRG1) ELISA Kit Customized Service Offer
  1. "Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis."Genes Dev. 12:3059-3073(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry."EMBO J. 19:6569-6581(2000) [PubMed] [Europe PMC] [Abstract]
  5. "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing."J. Biol. Chem. 276:42370-42381(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Large-scale proteomic analysis of the human spliceosome."Genome Res. 12:1231-1245(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular architecture of the human Prp19/CDC5L complex."Mol. Cell. Biol. 30:2105-2119(2010) [PubMed] [Europe PMC] [Abstract]