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Plexin A2 (PLXNA2)

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OCT; PLXN2; Semaphorin Receptor OCT

Plexin A2 (PLXNA2)
CCC H355
HGNC 9100
MGI 107684
PubMed 17339520
RGD 1305325
UniProt O75051
Wiki PLXNA2
PLXNA2encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.
PLXNA2 is associated with schizophrenia. and anxiety.The proteins encoded by all 4 genes contained large cytoplasmic domains characterized by a distinctive highly conserved sequence that they called the SEX domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Plexin A2 (PLXNA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Plexin A2 (PLXNA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Plexin A2 (PLXNA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Plexin A2 (PLXNA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Plexin A2 (PLXNA2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Plexin A2 (PLXNA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Plexin A2 (PLXNA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Plexin A2 (PLXNA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Plexin A2 (PLXNA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Plexin A2 (PLXNA2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Plexin A2 (PLXNA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Plexin A2 (PLXNA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Plexin A2 (PLXNA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Plexin A2 (PLXNA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Plexin A2 (PLXNA2) ELISA Kit Customized Service Offer
  1. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor."Proc. Natl. Acad. Sci. U.S.A. 93:674-678(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates."Cell 99:71-80(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of plexin A2 RBD in complex with RND1."Submitted (JAN-2011) to the PDB data bank