PLXN1 alone did not bind semaphorin-3A (SEMA3A), but the NRP1/PLXN1 complex had a higher affinity for SEMA3A than did NRP1 alone. While SEMA3A binding to NRP1 did not alter nonneuronal cell morphology, SEMA3A interaction with NRP1/PLXN1 complexes induced adherent cells to round up. Expression of a dominant-negative PLXN1 in sensory neurons blocked SEMA3A-induced growth cone collapse. SEMA3A treatment led to the redistribution of growth cone NRP1 and PLXN1 into clusters. Thus, the authors concluded that physiologic SEMA3A receptors consist of NRP1/PLXN1 complexes.The transmembrane protein they called NOV was identified by a cDNA found in a skeletal muscle cDNA library and shares 72% identity with SEX.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPH354Hu01 | Recombinant Plexin A1 (PLXNA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAH354Hu01 | Polyclonal Antibody to Plexin A1 (PLXNA1) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Plexin A1 (PLXNA1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Plexin A1 (PLXNA1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Plexin A1 (PLXNA1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Plexin A1 (PLXNA1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Plexin A1 (PLXNA1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Plexin A1 (PLXNA1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Plexin A1 (PLXNA1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Plexin A1 (PLXNA1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Plexin A1 (PLXNA1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Plexin A1 (PLXNA1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | SEH354Ra | ELISA Kit for Plexin A1 (PLXNA1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
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