Plexin A1 (PLXNA1)

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NOV; NOVP; PLXN1; Semaphorin receptor NOV

Plexin A1 (PLXNA1)
PLXN1 alone did not bind semaphorin-3A (SEMA3A), but the NRP1/PLXN1 complex had a higher affinity for SEMA3A than did NRP1 alone. While SEMA3A binding to NRP1 did not alter nonneuronal cell morphology, SEMA3A interaction with NRP1/PLXN1 complexes induced adherent cells to round up. Expression of a dominant-negative PLXN1 in sensory neurons blocked SEMA3A-induced growth cone collapse. SEMA3A treatment led to the redistribution of growth cone NRP1 and PLXN1 into clusters. Thus, the authors concluded that physiologic SEMA3A receptors consist of NRP1/PLXN1 complexes.The transmembrane protein they called NOV was identified by a cDNA found in a skeletal muscle cDNA library and shares 72% identity with SEX.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH354Hu01 Recombinant Plexin A1 (PLXNA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH354Hu01 Polyclonal Antibody to Plexin A1 (PLXNA1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Plexin A1 (PLXNA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Plexin A1 (PLXNA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Plexin A1 (PLXNA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Plexin A1 (PLXNA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Plexin A1 (PLXNA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Plexin A1 (PLXNA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Plexin A1 (PLXNA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Plexin A1 (PLXNA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Plexin A1 (PLXNA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Plexin A1 (PLXNA1) Polyclonal Antibody Customized Service Offer
Assay Kits SEH354Ra ELISA Kit for Plexin A1 (PLXNA1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]